The Role of Adenosine Receptor Activation in Attenuating Cartilaginous Inflammation

  • Jonathan M. Bekisz
  • Christopher D. Lopez
  • Carmen Corciulo
  • Aranzazu Mediero
  • Paulo G. Coelho
  • Lukasz Witek
  • Roberto L. Flores
  • Bruce N. Cronstein
REVIEW
  • 16 Downloads

Abstract

Adenosine receptor activation has been explored as a modulator of the inflammatory process that propagates osteoarthritis. It has been reported that cartilage has enhanced regenerative potential when influenced by adenosine receptor activation. As adenosine’s role in maintaining chondrocyte homeostasis at the cellular and molecular levels is explored, successful in vivo applications of adenosine delivery for cartilage repair continue to be reported. This review summarizes the role adenosine receptor ligation plays in chondrocyte homeostasis and regeneration of articular cartilage damaged in osteoarthritis. It also reports on all the modalities reported for delivery of adenosine through in vivo applications.

KEY WORDS

tissue engineering chondrocyte cartilage regeneration 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Jonathan M. Bekisz
    • 1
    • 2
  • Christopher D. Lopez
    • 3
    • 4
    • 5
  • Carmen Corciulo
    • 4
  • Aranzazu Mediero
    • 4
    • 6
  • Paulo G. Coelho
    • 2
    • 5
  • Lukasz Witek
    • 5
  • Roberto L. Flores
    • 2
  • Bruce N. Cronstein
    • 1
    • 4
  1. 1.New York University School of MedicineNew YorkUSA
  2. 2.Hansjörg Wyss Department of Plastic Surgery at New York University School of MedicineNew YorkUSA
  3. 3.Icahn School of Medicine at Mount SinaiNew YorkUSA
  4. 4.Division of Translational Medicine at New York University School of MedicineNew YorkUSA
  5. 5.Department of Biomaterials and Biomimetics at New York University College of DentistryNew YorkUSA
  6. 6.Bone and Joint Research UnitIIS-Fundación Jiménez Díaz UAMMadridSpain

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