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Inflammation

, Volume 39, Issue 2, pp 860–866 | Cite as

Different Expression of MicroRNA-146a in Peripheral Blood CD4+ T Cells and Lesions of Oral Lichen Planus

  • Jian-Guang Yang
  • Ya-Ru Sun
  • Guan-Ying Chen
  • Xue-Yi Liang
  • Jing Zhang
  • Gang ZhouEmail author
ORIGINAL ARTICLE

Abstract

Oral lichen planus (OLP) is a common T cell-mediated chronic inflammatory disease of unknown etiology. Recent increasing evidence indicates that microRNA-146a (miR-146a) plays a vital role in inflammatory diseases and T cell regulation. This study aimed to investigate the expression of miRNA-146a in peripheral blood CD4+ T cells and local OLP lesions and to evaluate its relationship with clinical forms of OLP. Sixteen patients with OLP were divided into two groups: erosive OLP and nonerosive OLP. The expression of miR-146a was examined by quantitative real-time polymerase chain reaction. The expression of miR-146a in peripheral blood CD4+ T cells showed no significant difference between OLP group and control group (P > 0.05), and among erosive OLP, nonerosive OLP, and control groups (P > 0.05 for all). The expression in local lesions of the OLP group was significantly higher than that of the control group (P = 0.003), and it was significantly higher in the erosive OLP group than in the non-erosive OLP (P = 0.010) and control groups (P = 0.007). However, miR-146a expression in the nonerosive OLP group did not significantly differ from that in the control group (P > 0.05). These data indicate that miR-146a might be more involved in the local immune disorder of OLP. MiR-146a might be utilized as a candidate biomarker to estimate the severity of OLP.

KEY WORDS

oral lichen planus microRNA-146a CD4+ T cells lesion 

Notes

Acknowledgments

This work was supported by grants from the National Natural Science Foundation of China (Nos. 81170972 and 81371147) to Gang Zhou.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no competing interests.

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Jian-Guang Yang
    • 1
  • Ya-Ru Sun
    • 1
  • Guan-Ying Chen
    • 1
  • Xue-Yi Liang
    • 1
  • Jing Zhang
    • 1
    • 2
  • Gang Zhou
    • 1
    • 2
    Email author
  1. 1.The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of StomatologyWuhan UniversityWuhanPeople’s Republic of China
  2. 2.Department of Oral Medicine, School and Hospital of StomatologyWuhan UniversityWuhanPeople’s Republic of China

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