Coenzyme Q10 Suppresses TNF-α-Induced Inflammatory Reaction In Vitro and Attenuates Severity of Dermatitis in Mice
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Anti-oxidant coenzyme Q10 (Co-Q10) is commonly used in clinic. Recently, Co-Q10 was reported to antagonize TNF-α-induced inflammation and play a protective role in various inflammatory conditions. However, its role in dermatitis is unknown. Herein, RAW264.7 macrophage cell line was cultured with stimulation of TNF-α, and administration of Co-Q10 alleviated TNF-α-mediated inflammatory reaction in vitro. Furthermore, oxazolone-induced dermatitis mice model was established, and treatment of Co-Q10 markedly attenuated dermatitis phenotype in this mice model. Moreover, the protective role of Co-Q10 in vitro and in dermatitis was probably due to its repression on NF-κB signaling. Collectively, Co-Q10 may represent a potential molecular target for prevention and treatment of inflammatory skin diseases.
KEY WORDScoenzyme Q10 TNF-α inflammation dermatitis NF-κB signaling
This research was supported partly by the Natural Science Foundation of Shandong Province (ZR2011CM022 to Ruifeng Li), Foundation of Shandong Province Outstanding Young Scientist Research Award (BS2014YY048 to Yunpeng Zhao), and a scientific research grant from Qilu Hospital of Shandong University (26010175616073 to Yunpeng Zhao).
Yunpeng Zhao and Weiwei Li are responsible for the study concept and design. Yunpeng Zhao, Weiwei Li, Xiaojuan Wu, Min Yang, and Ke Liang are responsible for the acquisition of data. Weiwei Li, Ruifeng Li, Wenhan Wang, Sijia Song, Linlin Guo, Ke Liang, and Xiangling Xu are responsible for the analysis and interpretation of data. Weiwei Li, Yunpeng Zhao, and Sijia Song are responsible for the statistical analysis. Weiwei Li, Yunpeng Zhao, Ruifeng Li, Wenhan Wang, and Xiaojuan Wu are responsible for the drafting of the manuscript.
Conflict of Interest
The authors declare that they do not have competing interests.
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