, Volume 39, Issue 1, pp 158–165 | Cite as

Inhibition of Radiation-Induced Oxidative Damage in the Lung Tissue: May Acetylsalicylic Acid Have a Positive Role?

  • Can Demirel
  • Sevil Cagiran Kilciksiz
  • Serkan Gurgul
  • Nurten Erdal
  • Seyran Yigit
  • Lulufer Tamer
  • Lokman Ayaz


The lung is relatively sensitive to irradiation. It is shown that acetylsalicylic acid (ASA) might reduce oxidative injury and that it has a place in protection from cancer. The aim of this study is to evaluate the potential radioprotective effects of ASA. Whole-body irradiation (6 Gy, single dose) was applied to the rats. Glutathione (GSH), malondialdehyde (MDA), myeloperoxidase (MPO), and nitric oxide (NO) levels in the lung tissue were measured. Control (C), Radiation (R), Radiation + ASA (R + ASA; received irradiation and 25 mg/kg of ASA intraperitoneally (i.p.)), and Radiation + Amifostine (R + WR-2721; received irradiation and 200 mg/kg of WR-2721 i.p.) groups were used. The MPO levels decreased statistically significantly in the group administered ASA. Histopathologically, a radioprotective effect of ASA was more evident in the R + ASA group. ASA is an agent which has not been used as a radioprotector in the clinic yet, and it is worth supporting with more advanced studies.


acetylsalicylic acid (ASA) irradiation injury lung myeloperoxidase WR-2721 


Conflict of interest

The authors declare that there is no conflict of interest.


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Can Demirel
    • 1
  • Sevil Cagiran Kilciksiz
    • 2
  • Serkan Gurgul
    • 3
  • Nurten Erdal
    • 4
  • Seyran Yigit
    • 5
  • Lulufer Tamer
    • 6
  • Lokman Ayaz
    • 7
  1. 1.Department of Biophysics, Faculty of MedicineGaziantep UniversityGaziantepTurkey
  2. 2.Department of Radiation OncologyKolan International HospitalIstanbulTurkey
  3. 3.Department of Biophysics, Faculty of MedicineGaziosmanpaşa UniversityTokatTurkey
  4. 4.Department of Biophysics, Faculty of MedicineMersin UniversityMersinTurkey
  5. 5.Department of PathologyIzmir Atatürk Training and Research HospitalIzmirTurkey
  6. 6.Department of Biochemistry, Faculty of MedicineMersin UniversityMersinTurkey
  7. 7.Department of Biochemistry, Faculty of PharmacyUniversity of TrakyaEdirneTurkey

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