Inflammation

, Volume 38, Issue 2, pp 527–533 | Cite as

Protective Effects of Embelin on Myocardial Ischemia–Reperfusion Injury Following Cardiac Arrest in a Rabbit Model

  • Zhi-Gang Zhao
  • Zhong-Zhi Tang
  • Wen-Kai Zhang
  • Jian-Guo Li
Article

Abstract

Embelin has been used to treat fever and inflammatory diseases for thousands of years. Although reports indicate that embelin has antiinflammatory effects, its effects on myocardial injury following cardiac arrest (CA) have not been previously explored. In this study, we aim to investigate the protective effects of embelin on myocardial ischemia–reperfusion injury (IRI) following CA in a rabbit model. Pro-inflammatory (TNF-α, IL-1β, and IL-6) cytokines, cardiac troponin I (cTnI), necrosis ratio, apoptotic index (AI), hemodynamics, nuclear factor-kappa B (NF-κB) p65, and histological damage have been measured or evaluated. Embelin reverts TNF-α, IL-1β, and IL-6 to basal levels and reduces the serum level of cTnI, the necrosis ratio, the AI, and the expression of NF-κB p65. Meanwhile, it improves the hemodynamics and myocardial function. Moreover, embelin-treated groups also showed improved myocardial morphology. Our results indicate that embelin may protect the heart against myocardial IRI following CA via its antiinflammatory abilities.

KEY WORDS

embelin antiinflammatory effects cardiac arrest myocardial ischemia–reperfusion injury 

Notes

Acknowledgments

We would like to thank the Center for Animal Experiment for the assistance in animal study.

Conflict of Interest

The authors declare no conflict of interest.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Zhi-Gang Zhao
    • 1
    • 2
  • Zhong-Zhi Tang
    • 2
  • Wen-Kai Zhang
    • 2
  • Jian-Guo Li
    • 1
  1. 1.Intensive Care UnitZhongnan Hospital of Wuhan UniversityWuhanChina
  2. 2.Emergency DepartmentWuhan General Hospital of Guangzhou Military CommandWuhanChina

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