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Inflammation

, Volume 37, Issue 5, pp 1826–1836 | Cite as

Gabapentin, a Synthetic Analogue of Gamma Aminobutyric Acid, Reverses Systemic Acute Inflammation and Oxidative Stress in Mice

  • Jordana Maia Dias
  • Tarcisio Vieira de Brito
  • Diva de Aguiar Magalhães
  • Pammela Weryka da Silva Santos
  • Jalles Arruda Batista
  • Eulina Gabriela do Nascimento Dias
  • Heliana de Barros Fernandes
  • Samara Rodrigues Bonfim Damasceno
  • Renan O. Silva
  • Karoline S. Aragão
  • Marcellus H. L. P. Souza
  • Jand-Venes R. Medeiros
  • André Luiz R. Barbosa
Article

Abstract

The aim of this study was to investigate the potential anti-inflammatory and anti-oxidant effects of gabapentin (GBP) in mice. The anti-inflammatory and anti-oxidant effects were evaluated using various mediators that induce paw edema, peritonitis model, myeloperoxidase (MPO) activity, proinflammatory cytokine levels, glutathione (GSH) consumption, and malondialdehyde (MDA) production in mice. Pretreatment of mice with GBP (1 mg/kg) significantly reduced carrageenan or dextran-induced paw edema (P < 0.05) when compared to vehicle group. Adding to this, GBP (1 mg/kg) significantly inhibited paw edema induced by histamine, serotonin, bradikinin, 48/80 compound, and prostaglandin E2. In the carrageenan-induced peritonitis model, GBP significantly decreased total and differential leukocyte counts and reduced the levels of MPO activity in the plantar tissue and IL-1β and TNF-α concentrations in the peritoneal exudate. The same dose of GBP also decreased the MDA concentration and increased the levels of GSH into the peritoneal fluid. In summary, our results demonstrated that GBP exhibited anti-inflammatory activity in mice by reducing the action of inflammatory mediators, neutrophil migration and proinflammatory cytokine levels, and anti-oxidant properties by decreasing the concentration of MDA and increasing the GSH content. These observations raise the possibility that GBP could be used to improve tissue resistance to damage during inflammatory conditions.

KEY WORDS

gabapentin anti-inflammatory effect anti-oxidant action 

Notes

Acknowledgments

The authors gratefully acknowledge the National Council of Technological and Scientific Development, CNPq, (Brazil) and the Research Foundation for the State of Piauí-Brazil (FAPEPI) for financially supporting this work.

Conflict of Interest

The authors report no conflict of interest.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Jordana Maia Dias
    • 1
  • Tarcisio Vieira de Brito
    • 1
  • Diva de Aguiar Magalhães
    • 1
  • Pammela Weryka da Silva Santos
    • 1
  • Jalles Arruda Batista
    • 1
  • Eulina Gabriela do Nascimento Dias
    • 1
  • Heliana de Barros Fernandes
    • 1
  • Samara Rodrigues Bonfim Damasceno
    • 2
  • Renan O. Silva
    • 2
  • Karoline S. Aragão
    • 2
  • Marcellus H. L. P. Souza
    • 2
  • Jand-Venes R. Medeiros
    • 1
  • André Luiz R. Barbosa
    • 1
  1. 1.LAFFEX—Laboratory of Experimental Physiopharmacology, Biotechnology and Biodiversity Center Research (BIOTEC)Federal University of PiauíParnaiba-PIBrazil
  2. 2.LAFICA—Laboratory of Pharmacology of Inflammation and Cancer, Department of Physiology and PharmacologyFederal University of CearáFortalezaBrazil

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