Inflammation

, Volume 37, Issue 4, pp 1091–1101

Protective Effect of Carvacrol on Acute Lung Injury Induced by Lipopolysaccharide in Mice

Article

Abstract

Carvacrol, the major component of Plectranthus amboinicus, has been known to exhibit anti-inflammatory activities. The aim of this study was to investigate the effects of carvacrol on lipopolysaccharide (LPS)-induced endotoxemia and acute lung injury (ALI) in mice. Mice were injected intraperitoneally (i.p.) with LPS and the mortality of mice for 7 days were observed twice a day. Meanwhile, the protective effect of carvacrol (20, 40 or 80 mg/kg) on LPS-induced endotoxemia were detected. Using an experimental model of LPS-induced ALI, we examined the effect of carvacrol in resolving lung injury. The results showed that carvacrol could improve survival during lethal endotoxemia and attenuate LPS-induced ALI in mice. The anti-inflammatory mechanisms of carvacrol may be due to its ability to inhibit NF-κB and MAPKs signaling pathways, thereby inhibiting inflammatory cytokines TNF-α, IL-6 and IL-1β production.

KEY WORDS

carvacrol acute lung injury LPS NF-κB MAPK 

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Guangdong Haid Institute of Animal Husbandry and VeterinaryGuangzhouChina

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