, Volume 38, Issue 3, pp 935–940 | Cite as

Increased Expression of T Cell Immunoglobulin and Mucin Domain 4 Is Positively Associated with the Disease Severity of Patients with Ankylosing Spondylitis

  • Dongdong Chen
  • Jianying He
  • Changchang Lu
  • Jihang Zhou
  • Kexin Fang
  • Xiaoguang Liu
  • Liyun Xu


Monocytes and associated cytokines have been shown to be involved in the pathogenesis of ankylosing spondylitis (AS). T cell immunoglobulin and mucin domain 4 (Tim-4) was identified on monocytes/macrophages and dentritic cells (DCs) and plays important roles in regulating the activities of macrophages and DCs. The current study investigated the association between Tim-4 expression and AS. Our results showed that Tim-4 expression on monocytes and Tim-4 level in plasma were highly increased in AS patients than in controls. Furthermore, TNF-α production and bath ankylosing spondylitis disease activity index (BASDAI) have positive relationships with Tim-4 expression in AS patients. High expression of Tim-4 was thought to contribute to the pathogenesis and an underlying mechanism of AS.


ankylosing spondylitis T cell immunoglobulin and mucin domain 4 tumor necrosis factor alpha monocyte HLA-B27 



This research was supported by a grant from the Zhejiang Provincial Natural Science Foundation of China (No. LQ13H100001).

Conflict of Interest

The authors have no financial interests to disclose.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Dongdong Chen
    • 1
  • Jianying He
    • 1
  • Changchang Lu
    • 1
  • Jihang Zhou
    • 1
  • Kexin Fang
    • 1
  • Xiaoguang Liu
    • 1
  • Liyun Xu
    • 1
  1. 1.Cell and Molecular Biology LaboratoryZhoushan HospitalZhoushan CityPeople’s Republic of China

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