Inflammation

, Volume 38, Issue 1, pp 424–432 | Cite as

Protective Effect of Intestinal Ischemic Preconditioning on Ischemia Reperfusion-Caused Lung Injury in Rats

  • Zhidong Wang
  • Yuanyuan Ji
  • Shufeng Wang
  • Rong Wang
  • Zongfang Li
  • Anjing Kang
  • Huili Xu
  • Min Shi
  • MinXia Zhao
Article
First Online:

Abstract

Intestinal ischemia reperfusion (IR) causes injury of distant critical organs. Remote intestinal ischemic preconditioning (IP) may confer the cytoprotection in critical organs including lung. The authors hypothesized that intestinal IP would be a prophylactic factor in the prevention of distant lung injury induced by IR. Rats were randomly divided into IR, IP, and Sham (S) group. Compared with IR group in the serum and lung tissue, MPO, MDA, TNF-α, and IL-1 levels were significantly decreased in the IP group. Following the same pattern, NO level in the serum and lung tissue was significantly increased in the IP group. And intestinal IP markedly abolished lung injury scores in contrast to IR group. Moreover, intestinal IP significantly attenuated caspase-3 expression, leading to the low expression of Bax and the high expression of Bcl-2. The present study showed that intestinal IP ameliorates the capacity of anti-oxygen free radical, inhibits the release of pro-inflammatory cytokines and alleviates apoptosis in IR-induced lung injury in rats. Intestinal IP may provide a novel prophylactic strategy for treatment of IR-induced lung injury.

KEY WORDS

ischemic preconditioning ischemia reperfusion lung injury apoptosis 
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Notes

Acknowledgments

This study was supported by the Fundamental Research Funds for the Central Universities (2013JDHZ08) and Specialized Research Fund of the Second Affiliated Hospital of Xi’an Jiaotong University School of Medicine of China, No. RC (XM) 201103.

Conflict of Interests

The authors have declared that no competing interests exist.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Zhidong Wang
    • 1
  • Yuanyuan Ji
    • 2
  • Shufeng Wang
    • 3
  • Rong Wang
    • 3
  • Zongfang Li
    • 1
  • Anjing Kang
    • 4
  • Huili Xu
    • 1
  • Min Shi
    • 1
  • MinXia Zhao
    • 1
  1. 1.Department of VIP General SurgeryThe Second Affiliated Hospital, Xi’an Jiaotong UniversityXi’anChina
  2. 2.Scientific Research CentreThe Second Affiliated Hospital, Xi’an Jiaotong UniversityXi’anChina
  3. 3.Department of General SurgeryThe First Affiliated Hospital, Xi’an Jiaotong UniversityXi’anChina
  4. 4.Department of Pathology, The Second Affiliated HospitalXi’an Jiaotong UniversityXi’anChina

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