Inflammation

, Volume 36, Issue 6, pp 1453–1459 | Cite as

Valproic Acid Attenuates Lipopolysaccharide-Induced Acute Lung Injury in Mice

  • Mu-huo Ji
  • Guo-min Li
  • Min Jia
  • Si-hai Zhu
  • Da-peng Gao
  • Yun-xia Fan
  • Jing Wu
  • Jian-jun Yang
Article

Abstract

Valproic acid (VPA) has been shown to exert anti-inflammatory and antioxidant effects in a range of diseases including septic shock. However, the effects of VPA on lipopolysaccharide (LPS)-induced acute lung injury (ALI) remains not well understood. We found that VPA pretreatment attenuated the LPS-induced ALI, as evidenced by the reduced histological scores, myeloperoxidase activity, and wet-to-dry weight ratio in the lung tissues. This was accompanied by the downregulated nuclear factor kappa B (NF-κB) p65, nitric oxide, and inducible nitric oxide synthase in the lung tissues and the decreased levels of tumor necrosis factor alpha and interleukin-1β in the bronchoalveolar lavage fluid. Furthermore, VPA reduced the nuclear histone deacetylase (HDAC)3 expression whereas increased the cytoplasmic HDAC3 expression. Our results suggested that VPA attenuates the LPS-induced ALI via inhibiting the NF-κB activation probably through a mechanism depending on HDAC3 redistribution.

KEY WORDS

sepsis pro-inflammatory cytokine HDACs acute lung injury 

Notes

Acknowledgments

This work was supported by the Natural Science Foundation of Jiangsu Province (BK2012778).

Conflict of Interest

The authors have no potential conflicts of interest to disclose.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Mu-huo Ji
    • 1
  • Guo-min Li
    • 2
  • Min Jia
    • 1
  • Si-hai Zhu
    • 1
  • Da-peng Gao
    • 1
  • Yun-xia Fan
    • 2
  • Jing Wu
    • 1
  • Jian-jun Yang
    • 1
  1. 1.Department of Anesthesiology, Jinling Hospital, School of MedicineNanjing UniversityNanjingChina
  2. 2.Department of Anesthesiology and Intensive Care, Jintan HospitalJiangsu UniversityChangzhouChina

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