Inflammation

, Volume 36, Issue 6, pp 1279–1285 | Cite as

Urinary Trypsin Inhibitor Attenuated Inflammatory Response of Patients Undergoing Cardiopulmonary Bypass by Inducing Activated Treg Cells

  • Xing Hao
  • Junyan Han
  • Zhichen Xing
  • Yu Hao
  • Chunjing Jiang
  • Jianping Zhang
  • Jing Yang
  • Xiaotong Hou
Article

ABSTRACT

The urinary trypsin inhibitor (ulinastatin) is used in the clinic to prevent inflammatory responses in patients undergoing cardiopulmonary bypass (CPB); however, the anti-inflammatory mechanism is unclear. In the current study, we recruited 40 patients undergoing selective cardiac valve replacement surgery; and these patients were randomly divided into two groups (ulinastatin group [UG] and control group [CG]). We collected peripheral blood preoperatively, at the end of CPB, and postoperative days 1 and 3 and analyzed the kinetic changes in regulatory T (Treg) cell subsets. There was no statistically significant difference in the number of CD4+ T cells between the two groups. The number of CD4+CD25+ Treg cells, especially the suppressive activated Treg (aTreg) subset, was higher in the UG than the CG 1 and 3 days postoperatively. Thus, ulinastatin alleviated the inflammatory response during CPB by inducing the expansion of aTreg cells.

KEY WORDS

cardiopulmonary bypass inflammation responses ulinastatin regulatory T cells 

ABBREVIATIONS

CPB

Cardiopulmonary bypass

TNF-α

Tumor necrosis factor-alpha

IL

Interleukin

AAo

Ascending aorta

CRP

C-reactive protein

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Xing Hao
    • 1
  • Junyan Han
    • 2
    • 3
  • Zhichen Xing
    • 1
  • Yu Hao
    • 2
    • 3
  • Chunjing Jiang
    • 1
  • Jianping Zhang
    • 2
    • 3
  • Jing Yang
    • 1
  • Xiaotong Hou
    • 1
  1. 1.Department of Extracorporeal Circulation, Center for Cardiac Intensive Care, Beijing Anzhen HospitalCapital Medical UniversityBeijingChina
  2. 2.Beijing Key Laboratory of Emerging Infectious DiseasesBeijingChina
  3. 3.Institute of Infectious Diseases, Beijing Ditan HospitalCapital Medical UniversityBeijingChina

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