, Volume 36, Issue 6, pp 1232–1238 | Cite as

Interaction of Metabolic Syndrome with Asthma in Postmenopausal Women: Role of Adipokines

  • Murat AydinEmail author
  • Cemile Koca
  • Duygu Ozol
  • Sema Uysal
  • Zeki Yildirim
  • Havva Sahin Kavakli
  • M. Ramazan Yigitoglu


The increasing prevalence of both asthma and obesity are major health problems. Recent studies established a possible link between obesity and asthma; however, the underlying mechanism is not clear. The aim of the study was to analyze the prevalence of metabolic syndrome in postmenopausal subjects with asthma and search the interactions between adipokines, metabolic syndrome, and asthma. A total of 45 female patients (57.5 ± 13.9 years) with asthma and 30 healthy subjects (59.6 ± 12.8 years) in postmenopausal status were enrolled in this study. For the diagnosis of metabolic syndrome, modified World Health Organization diagnostic criteria were used. Blood levels of glucose, lipid profile, HbA1c, insulin, CRP, leptin, adiponectin, tumor necrosis factor-alpha, interleukin (IL)-6, IL-8 and plasminogen activator inhibitor-1 (PAI-1) were measured. The mean body mass index was 29.6 ± 5.4 for asthma patients and 28.2 ± 5.3 for the control group. The incidence of metabolic syndrome was found as 26 % for both groups. Insulin resistance as calculated by homeostasis model assessment (HOMA-IR) and fasting insulin levels were significantly higher in asthma patients (p < 0.001 for both parameters). Leptin levels were significantly higher (p = 0.001) and adiponectin levels were lower (p = 0.029) in asthma patients compared to controls. We concluded that although incidence of obesity and metabolic syndrome was not higher in postmenopausal asthma patients than controls, there was an impairment of glucose metabolism and altered adipokine levels in asthma patients.


adiponectin adipose tissue insulin resistance inflammation leptin asthma 



The authors wish to express their sincere appreciation to the study participants and to Fatih University. This work was financially supported by the Scientific Research Fund of Fatih University under the project number P53010703.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Murat Aydin
    • 1
    Email author
  • Cemile Koca
    • 2
  • Duygu Ozol
    • 3
  • Sema Uysal
    • 4
  • Zeki Yildirim
    • 3
  • Havva Sahin Kavakli
    • 5
  • M. Ramazan Yigitoglu
    • 4
  1. 1.Department of Biochemistry, Faculty of MedicineNamık Kemal UniversityMerkez-TekirdagTurkey
  2. 2.Medical Biochemistry LaboratoryYildirim Beyazit University, Ankara Ataturk Training and Research HospitalAnkaraTurkey
  3. 3.Department of PulmonologyTurgut Ozal University Faculty of MedicineAnkaraTurkey
  4. 4.Department of BiochemistryTurgut Ozal University Faculty of MedicineAnkaraTurkey
  5. 5.Department of Emergency MedicineYildirim Beyazit University, Ankara Ataturk Training and Research HospitalAnkaraTurkey

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