, Volume 36, Issue 3, pp 696–704 | Cite as

Interaction Between Oral Lichen Planus and Chronic Periodontitis with Th17-Associated Cytokines in Serum

  • Hui Wang
  • Zhenhua Luo
  • Lei Lei
  • Zheng Sun
  • Min Zhou
  • Hongxia Dan
  • Xin Zeng
  • Qianming Chen


The objective of this study was to compare the expression levels of interleukin (IL)-17 IL-17 and IL-23 in serum from patients with both oral lichen planus and chronic periodontitis (OLP-CP), patients only with oral lichen planus (OLP), patients only with chronic periodontitis (CP), and healthy controls (HC). The serum samples were collected from 35 OLP-CP patients, 35 OLP patients, 30 CP patients, and 30 healthy controls. ELISA test was used to detect expression levels of IL-17 and IL-23 in serum from these four groups. ELISA analysis showed significantly elevated levels of serum IL-17 in OLP-CP group compared with OLP group (P < 0.05) and HC group (P < 0.01). Serum IL-23 result showed that there was an increased expression level in OLP-CP compared with HC group (P < 0.01). Additionally, female OLP-CP group showed elevated level of serum IL-17 compared with female OLP group, and also erosive OLP-CP group demonstrated increased serum IL-17 level compared with erosive OLP group. Moreover, analysis showed positive significant correlations of serum IL-17 level with probing depth (P < 0.05) and plaque index (P < 0.05) in erosive OLP-CP patients. This study indicates that OLP-CP patients get higher expression level of serum IL-17 and had susceptibility to erosive or female subtype, which indicated that IL-17 may participate in the disease immunopathogenesis of both common oral diseases.


oral lichen planus periodontitis interleukin-17 interleukin-23 



This work was supported by grants from the National Natural Science Foundation of China (nos. 81200791, 81072218, 30930100) and by the Doctoral Program of the Ministry of Education of China (no. 20110181110055). We thank the statistician Dr. Xia QJ from the School of Public Health for his kind help with data analysis. Thanks very much for the editors and reviewers’ kind work in improving our manuscript.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Oral Medicine, School of StomatologyCapital Medical UniversityBeijingChina
  2. 2.Department of Periodontics, West China College of Stomatology, State Key Laboratory of Oral DiseasesSichuan UniversityChengduChina
  3. 3.Department of Oral Medicine, West China College of Stomatology, State Key Laboratory of Oral DiseasesSichuan UniversityChengduChina
  4. 4.Department of Molecular Pathology, State Key Laboratory of Oral DiseasesSichuan UniversityChengduChina

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