Inflammation

, Volume 36, Issue 2, pp 468–475 | Cite as

Effect of Lipoxin A4 on Myocardial Ischemia Reperfusion Injury Following Cardiac Arrest in a Rabbit Model

  • Zhiqiao Chen
  • Zhe Wu
  • Congxin Huang
  • Yan Zhao
  • Yirong Zhou
  • Xianlong Zhou
  • Xingxing Lu
  • Lele Mao
  • Siying Li
Article

Abstract

In the present study, we investigated the effect of lipoxin A4 on myocardial ischemia–reperfusion injury (IRI) following cardiac arrest (CA) in a rabbit model. Lipoxin A4 is a metabolite of arachidonic acid in the eicosanoid, it is called “brake signal” for its anti-inflammatory activity. Some inflammatory factors (IL-1β, IL-6, TNF-α, and IL-10), NF-κB p65, infarct ratios, apoptotic index, cardiac troponin I (cTnI), hemodynamic and myocardial structures were measured or observed in different groups. Lipoxin A4 inhibits the expression of IL-1β, IL-6, and TNF-α, the values of the infarct ratios, apoptotic index, the level of serum cTnI and NF-κB p65. Meanwhile, it improves the expression of IL-10, hemodynamic, myocardial structure, and function. These indicate that lipoxin A4 mitigates postresuscitation myocardial IRI in which anti-inflammation and suppression of NF-κB activation may play an important role.

KEY WORDS

cardiac arrest (CA) cardiopulmonary resuscitation (CPR) ischemia–reperfusion injury (IRI) inflammation lipoxin A4 

Notes

Acknowledgments

All authors would like to thank for Professor Yangan Wang for reviewing the manuscript. We are grateful to the staff of the Emergency Center and Inspection Department of Zhongnan Hospital for their help in sample testing and data acquisition.

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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Zhiqiao Chen
    • 1
    • 2
  • Zhe Wu
    • 3
  • Congxin Huang
    • 4
  • Yan Zhao
    • 2
  • Yirong Zhou
    • 3
  • Xianlong Zhou
    • 3
  • Xingxing Lu
    • 3
  • Lele Mao
    • 3
  • Siying Li
    • 3
  1. 1.Renmin Hospital of Wuhan UniversityWuhanPeople’s Republic of China
  2. 2.Emergency CenterZhongnan Hospital of Wuhan UniversityWuhanPeople’s Republic of China
  3. 3.Medical College of Wuhan UniversityWuhanPeople’s Republic of China
  4. 4.Department of CardiologyRenmin Hospital of Wuhan UniversityWuhanPeople’s Republic of China

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