Inflammation

, Volume 35, Issue 2, pp 684–689 | Cite as

Association Between C-Reactive Protein and Type 2 Diabetes in a Tunisian Population

  • Hanen Belfki
  • Samir Ben Ali
  • Souha Bougatef
  • Decy Ben Ahmed
  • Najet Haddad
  • Awatef Jmal
  • Monia Abdennebi
  • Habiba Ben Romdhane
Article

Abstract

The aim of this study was to investigate the association of CRP levels with type 2 diabetes (T2D) and its related variables in a sample of the Tunisian population. Our sample included 129 patients with T2D and 187 control subjects. Body mass index (BMI), plasma lipids, glucose, insulin, and CRP concentrations were measured for each participant. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. T2D was defined as a fasting plasma glucose (FPG) level ≥ 7.0 mmol/L, the use of anti-diabetic drugs, or both. Statistical analyses were performed using SPSS 11.5. A significant difference in mean values of BMI, plasma lipids, FPG, insulin, and HOMA-IR was observed between subjects with and without T2D. CRP level was significantly higher in subjects with T2D than those without (p = 0.023), and this result persisted even after adjustment for age, gender, BMI, smoking, and alcohol consumption. In both diabetes statuses, log CRP was significantly associated with FPG, insulin, and HOMA-IR. Subjects with elevated CRP levels (>5 mg/L) had an increased risk of T2D (OR = 2.02, 95% CI 1.18–3.46, p = 0.010) than those whose CRP levels were less or equal to 5 mg/L. Even after adjustment for potentially confounding factors, the risk of T2D was still increased in subjects with elevated CRP levels (OR = 1.91, 95% CI 1.08–3.36, p = 0.025). These results suggest that elevated CRP levels are independently associated with T2D.

KEY WORDS

C-reactive protein inflammation type 2 diabetes insulin resistance 

Notes

ACKNOWLEDGMENTS

This work was supported by a grant from The “Ministry of Higher Education, Scientific Research and Technology” of Tunisia.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Hanen Belfki
    • 1
  • Samir Ben Ali
    • 1
  • Souha Bougatef
    • 1
  • Decy Ben Ahmed
    • 3
  • Najet Haddad
    • 3
  • Awatef Jmal
    • 2
  • Monia Abdennebi
    • 2
  • Habiba Ben Romdhane
    • 1
  1. 1.Laboratory of Epidemiology and Prevention of Cardiovascular Disease, Faculty of MedicineUniversity of Tunis El-ManarTunisTunisia
  2. 2.Laboratory of Medical BiologyMahmoud El-Matri Hospital of ArianaTunisTunisia
  3. 3.Center of Basic Health Care of Ariana EssoghraTunisTunisia

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