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Inflammation

, Volume 35, Issue 2, pp 623–632 | Cite as

Diospyros blancoi Attenuates Asthmatic Effects in a Mouse Model of Airway Inflammation

  • Kyoung-Youl Lee
  • Ju-Young Jung
  • Mee-Young Lee
  • Dayoung Jung
  • Eun-Sang Cho
  • Hwa-Young Son
Article

Abstract

Asthma is a complex disease linked to various pathophysiological events, including proteinase activity. In this study, we examined whether a Diospyros blancoi methanolic extract (DBE) exerts protective effects on allergic asthma in a murine asthma model. To investigate the specific role of DBE, we employed a murine model of allergic airway inflammation. BALB/c mice sensitized and challenged with ovalbumin (OVA) were orally administered 20 or 40 mg/kg DBE for 3 days during OVA challenge. DBE induced significant suppression of the number of OVA-induced total inflammatory cells, including eosinophils, macrophages, and lymphocytes, in bronchoalveolar lavage fluid (BALF). Moreover, treatment with DBE led to significant decreases in interleukin (IL)-4, IL-5, and eotaxin levels in BALF and OVA-specific immunoglobulin (Ig)E and IgG1 levels in serum. Histological examination of lung tissue revealed marked attenuation of allergen-induced lung eosinophilic inflammation and mucus-producing goblet cells in the airway. Additionally, DBE suppressed matrix metalloproteinase-9 activity and induced heme oxygenase-1 expression. The present findings collectively suggest that DBE exhibits anti-inflammatory activity in an airway inflammation mouse model, supporting its therapeutic potential for the treatment of allergic bronchial asthma.

KEY WORDS

asthma eosinophilia cytokine inflammation 

Notes

ACKNOWLEDGMENTS

This study is based on a “Human Resource Development Center for Economic Region Leading Industry” Project supported by the Ministry of Education, Science and Technology (MEST) and the National Research Foundation of Korea (NRF).

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Kyoung-Youl Lee
    • 1
  • Ju-Young Jung
    • 2
  • Mee-Young Lee
    • 3
  • Dayoung Jung
    • 4
  • Eun-Sang Cho
    • 2
  • Hwa-Young Son
    • 5
  1. 1.Department of HealthKongju National UniversityKongjuSouth Korea
  2. 2.College of Veterinary MedicineChungnam National UniversityDaejeonSouth Korea
  3. 3.Herbal Medicine EBM Research CenterKorea Institute of Oriental MedicineDaejeonSouth Korea
  4. 4.Department of PharmacologyChungnam National UniversityDaejeonSouth Korea
  5. 5.College of Veterinary Medicine & Graduate School of New Drug Discovery and DevelopmentChungnam National UniversityDaejeonSouth Korea

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