Inflammation

, Volume 34, Issue 6, pp 551–558 | Cite as

Dynamics of Inflammatory Markers in Post-Acute Stroke Patients Undergoing Rehabilitation

  • Bogdan Nicolae Manolescu
  • Mihai Berteanu
  • Luminița Dumitru
  • Horațiu Dinu
  • Alina Iliescu
  • Ileana Cornelia Fărcășanu
  • Eliza Oprea
  • Suzana Vlădoiu
  • Oana Popa
  • Olga Ianăș
Article
First Online:

Abstract

Stroke is a pathological condition associated with an enhanced inflammatory response that has a multifactorial etiology. We evaluated the dynamic of plasma concentrations of IL-1α, IL-6, IL-8, TNF-α, soluble form of intercellular adhesion molecule 1, and lipoprotein (a) [Lp(a)] during the rehabilitation of post-acute stroke patients (n = 20), in parallel with control subjects (n = 24). Stroke patients had significantly increased concentrations of IL-6, TNF-α, and Lp(a) when compared to healthy controls. It was found that the changes in the IL-6, IL-8, and TNF-α concentrations associated with the pathological condition were statistically significant (χ 2 = 4.81, p = 0.028, χ 2 = 10.40, p = 0.005 and χ 2 = 6.73, p = 0.034, respectively). The decrease of Lp(a) during the rehabilitation had statistical significance (p = 0.043), while the decrease of IL-1α had marginal significance (p = 0.071). IL-1α, TNF-α, and Lp(a) concentrations were significantly negatively correlated with the Barthel index values, suggesting that the decrease of these inflammatory markers was beneficial for patients’ recovery.

KEY WORDS

stroke Barthel index rehabilitation IL-1α TNF-α lipoprotein (a) 

ABBREVIATIONS

NF-kB

Nuclear factor kB

HIF-1

Hypoxia-inducible factor-1

IRF-1

Interferon regulatory factor 1

STAT3

Signal transducer and activator of transcription 3

ICAM-1

Intercellular adhesion molecule 1

TNF-α

Tumor necrosis factor α

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Bogdan Nicolae Manolescu
    • 1
  • Mihai Berteanu
    • 2
    • 3
  • Luminița Dumitru
    • 2
    • 3
  • Horațiu Dinu
    • 3
  • Alina Iliescu
    • 2
    • 3
  • Ileana Cornelia Fărcășanu
    • 4
  • Eliza Oprea
    • 4
  • Suzana Vlădoiu
    • 5
  • Oana Popa
    • 5
  • Olga Ianăș
    • 5
  1. 1.Department of Biochemistry, Faculty of MedicineUniversity of Medicine and Pharmacy “Carol Davila”BucharestRomania
  2. 2.Department of Rehabilitation and Physical Medicine, Faculty of MedicineUniversity of Medicine and Pharmacy “Carol Davila”BucharestRomania
  3. 3.Department of Rehabilitation and Physical MedicineElias University Emergency HospitalBucharestRomania
  4. 4.Department of Organic Chemistry, Faculty of ChemistryUniversity of BucharestBucharestRomania
  5. 5.National Institute of Endocrinology “C.I. Parhon”BucharestRomania

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