, Volume 34, Issue 1, pp 67–71 | Cite as

Effect of Fructose-1,6-bisphosphate on the Nephrotoxicity Induced by Cisplatin in Rats

  • Alan Arrieira Azambuja
  • Adroaldo Lunardelli
  • Fernanda Bordignon Nunes
  • Patrick Barcelos Gaspareto
  • Márcio Vinícius Fagundes Donadio
  • Carlos Eduardo Poli de Figueiredo
  • Jarbas Rodrigues de Oliveira


Cisplatin is one of the most active cytotoxic agents in the treatment of cancer, but its clinical use is frequently limited by nephrotoxicity. The study presented here attempted to evaluate the effect of fructose-1,6-bisphosphate in the cisplatin-induced nephrotoxicity in rats. The drugs were administered intraperitoneally as a single dose: sodium chloride 0.9%, cisplatin (6 mg/kg), fructose-1,6-bisphosphate (500 mg/kg), and cisplatin plus fructose-1,6-bisphosphate (6 and 500 mg/kg, respectively). The use of cisplatin resulted in significant elevation of serum creatinine and urea. The group that received cisplatin plus fructose-1,6-bisphosphate presented a significantly lower level of creatinine and urea compared to the cisplatin group. Acute tubular necrosis was demonstrated in the animals that received cisplatin and a less severe one in the cisplatin plus fructose-1,6-bisphosphate group. Fructose-1,6-bisphosphate has a protective effect over renal function and renal parenchyma in a rat experimental model of cisplatin-induced nephrotoxicity. The anti-inflammatory effect of fructose-1,6-bisphosphate confirms its protective effect in cases of cellular injury.


cisplatin fructose-1,6-bisphosphate nephrotoxicity tubular necrosis 


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Alan Arrieira Azambuja
    • 1
  • Adroaldo Lunardelli
    • 2
  • Fernanda Bordignon Nunes
    • 2
  • Patrick Barcelos Gaspareto
    • 3
  • Márcio Vinícius Fagundes Donadio
    • 2
    • 4
  • Carlos Eduardo Poli de Figueiredo
    • 1
  • Jarbas Rodrigues de Oliveira
    • 2
  1. 1.Hospital São Lucas da Pontifícia Universidade Católica do Rio Grande do Sul (HSL PUCRS)Porto AlegreBrasil
  2. 2.Laboratório de Pesquisa em Biofísica Celular e Inflamação, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)Porto AlegreBrasil
  3. 3.Hospital Universitário da Universidade Federal de Santa Catarina (HU UFSC)FlorianópolisBrasil
  4. 4.Faculdade de Enfermagem, Nutrição e FisioterapiaPontifícia Universidade Católica do Rio Grande do Sul (PUCRS)Porto AlegreBrasil

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