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Inflammation

, Volume 33, Issue 5, pp 320–324 | Cite as

Asthma and Dehydroepiandrosterone (DHEA): Facts and Hypotheses

  • Alicja Kasperska-ZajacEmail author
Article

Abstract

Dehydroepiandrosterone (DHEA) is considered as an important immunomodulating and anti-inflammatory hormone. Despite the continuing interest in DHEA replacement therapy, our knowledge of its effects upon asthma is very limited. DHEA is able to reverse cytokine imbalances associated with asthma, may prevent and attenuate allergic inflammation in airways, and does not possess the undesirable side effects of glucocorticoids; therefore, it may be potentially applied in the treatment of asthma. The steroid-sparing effect observed with DHEA clinically could appear especially favorable in asthmatic patients receiving oral treatment and those inhaling high doses of glucocorticoids. In addition, DHEA and its analogs might prove useful in reversing relative glucocorticoids insensitivity in patients with corticosteroid-resistant asthma. In this review we have focused specifically on DHEA’s role in asthma.

KEY WORDS

dehydroepiandrosterone asthma 

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Clinical Department of Internal Diseases, Allergology and Clinical ImmunologyMedical University of SilesiaKatowicePoland

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