Inflammation

, 31:260 | Cite as

Anti-neutrophil Cytoplasmic Antibodies in New-onset Systemic Lupus Erythematosus and Lupus Nephritis

  • Hai-Feng Pan
  • Xue-Hui Fang
  • Guo-Cui Wu
  • Wen-Xian Li
  • Xue-Fei Zhao
  • Xiang-Pei Li
  • Jian-Hua Xu
  • Dong-Qing Ye
Article

Abstract

This study aims to investigate the role of Antineutrophil cytoplasmic antibodies (ANCA) in patients with new-onset systemic lupus erythematosus (SLE). Sixty SLE patients, 28 of whom had lupus nephritis (LN), and 60 normal controls were enrolled; Serum ANCA was measured by enzyme linked immunosorbent assay (ELISA). The clinical and laboratory parameters of the patients were also recorded. Results show that twenty SLE patients were seropositive for ANCA, which was significantly higher than in normal controls. LN patients had significantly higher positive rate of ANCA than patients without nephritis. Compared with ANCA-negative patients, the ANCA-positive patients had significantly higher incidence of nerves system disorder, myocarditis, renal involvement and serositis. The positive rate of γ-globulin, anti-dsDNA and anti-Sm antibodies were significantly higher in ANCA-positive patients. Elevated IgG and ESR, decreased serum C3/C4 appeared more often in ANCA-positive patients. In addition, serum ANCA level correlated positively with disease activity. Taken together, ANCA might be used as a potential complementary parameter to differentiate LN from SLE without nephritis. In addition, ANCA may serve as a useful marker of the disease activity of SLE.

KEY WORDS

ANCA disease activity nephritis systemic lupus erythematosus 

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Hai-Feng Pan
    • 1
  • Xue-Hui Fang
    • 1
  • Guo-Cui Wu
    • 4
  • Wen-Xian Li
    • 1
  • Xue-Fei Zhao
    • 1
  • Xiang-Pei Li
    • 2
  • Jian-Hua Xu
    • 3
  • Dong-Qing Ye
    • 1
  1. 1.Department of Epidemiology and Biostatistics, School of Public HealthAnhui Medical UniversityHefeiPeople’s Republic of China
  2. 2.Department of RheumatologyAnhui Provincial HospitalHefeiChina
  3. 3.Department of Rheumatology, First Affiliated HospitalAnhui Medical UniversityHefeiChina
  4. 4.Department of PharmacologyAnhui Medical UniversityHefeiChina

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