A novel hybrid nanoparticle based on Fe3O4/TMAOH/poly(L-co-D,L lactic acid-co-trimethylene carbonate) prepared through the solvent displacement method
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TMAOH-dispersed nanoparticles of magnetite were first prepared through the reduction–precipitation of ferric chloride with Na2SO3 and NH4OH. The TMAOH-dispersed (Fe3O4) magnetic nanoparticles were then surface-coated with poly(L-co-D,L lactic acid-co-trimethylene carbonate) (PLDLA-co-TMC) to obtain the corresponding hybrid system (Fe3O4/TMAOH/PLDLA-co-TMC). Samples of so prepared material were analyzed by Fourier-transform infrared spectroscopy (FTIR), powder X-ray diffraction (XRD), magnetization measurements up to 2.5 T, and Mössbauer spectroscopy. Results indicate that this magnetic iron oxide soon after the synthesis is structurally close enough to a typically pure stoichiometric magnetite. FTIR data support clears evidences confirming the efficiency of the solvent displacement method to assure coating the TMAOH-dispersed (Fe3O4) magnetic nanoparticles with the terpolymer while preserves the main chemical structural characteristic of the nanosized magnetite.
KeywordsMagnetite Hybrid nanoparticles Biomaterial
JD Fabris and LCD Cavalcante are indebted to the Brazilian National Council for the Scientific and Technological Development (CNPq), for the financial support under the grants # 304958-2017-4 and # 313431/2017-5, respectively. The Brazilian Coordination for the Improvement of Higher Education Personnel (CAPES) granted a DSc studenship to VO Machado at Military Insitute of Engineering (Brazil).
- 5.Khalkhali, M., Rostamizadeh, K., Sadighian, S., Khoeini, F., Naghibi, M., Hamidi, M.: The impact of polymer coatings on magnetite nanoparticles performance as MRI contrast agents: a comparative study. DARU J. Pharm. Sci. 23(45), (2015). https://doi.org/10.1186/s40199-015-0124-7
- 7.Couvreur, P., Barratt, G., Fattal, E., Legrand, P., Vauthier, C.: Nanocapsule technology: a review. Crit. Rev. Ther. Drug Carrier Syst. 19(2), 99–134 (2002). https://doi.org/10.1615/CritRevTherDrugCarrierSyst.v19.i2.10 CrossRefGoogle Scholar
- 8.Andrade, A.L., Fabris, J.D., Ardisson, J.D., Valente, M.A., Ferreira, J.M.F.: Effect of tetramethylammonium hydroxide on nucleation, surface modification and growth of magnetic nanoparticles. J. Nanomater. Article ID 454759. 10 (2012). https://doi.org/10.1155/2012/454759
- 13.Mas, B.A., Cattani, S.M.M., Rangel, R.C.C., Ribeiro, G.A., Cruz, N.C., Leite, F.L., Nascente, P.A.P., Duek, E.A.R.: Surface characterization and osteoblast-like cells culture on collagen modified PLDLA scaffolds. Mater. Res. 17(6), 1523–1534 (2014). https://doi.org/10.1590/1516-1439.269414 CrossRefGoogle Scholar
- 17.Saritha, A., Shastri, N.: Preparation, physico chemical characterization of solid dispersions of tenoxicam with poloxamer. J. Pharm. Sci. Technol. 2(9), 308–311 (2010)Google Scholar
- 19.Komatsu, D., Mistura, D.V., Motta, A., Domingues, J.A., Hausen, M.A., Duek, E.: Development of a membrane of poly (L-co-D,L lactic acid-co-trimethylene carbonate) with aloe vera: an alternative biomaterial designed to improve skin healing. J. Biomater. Appl. 32(3), 311–320 (2017). https://doi.org/10.1177/0885328217719854 CrossRefGoogle Scholar
- 20.Jayakrishnan, P., Ramesan, M.T.: Studies on the effect of magnetite nanoparticles on magnetic, mechanical, thermal, temperature dependent electrical resistivity and DC conductivity modeling of poly (vinyl alcohol-co-acrylic acid)/Fe3O4 nanocomposites. Mater. Chem. Phys. 186, 513–522 (2017). https://doi.org/10.1016/j.matchemphys.2016.11.028 CrossRefGoogle Scholar