119Sn Mössbauer study of Sn-containing radiopharmaceutical kits
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Sn-containing radiopharmaceutical kits, MULTIBONE (composed from stannous chloride dihydrate and EDTMP (ethylene-diamine-tetramethylene phosphonate) and PHYTON (composed from stannous chloride dihydrate and PHYTATE (myo-inositol-hexaphosphate ester) kits, to be used for monitoring in liver tumor therapy, were characterized by 119Sn Mössbauer spectroscopy and XRD measurements. XRD revealed the amorphous nature of the Sn-containing compounds. 80 K 119Sn Mössbauer spectra of both compounds indicated the dominant presence of tin(II) state with characteristic Mössbauer parameters of δ = 3.12 ± 0.01 mms−1 and Δ = 1.84 ± 0.02 mms−1 as well as δ = 3.01 ± 0.01 ± 0.01 mms−1 and Δ = 1.73 ± 0.02 mms−1 for Sn-PHYTATE and Sn-EDTMP, respectively. The occurrence of tin(IV) in Sn-MULTIBONE was as low as measured in the precursor stannous chloride dihydrate (∼3%).
Keywords119Sn Mössbauer spectroscopy Pharmaceutical kits Sn-Phytate Sn-Multibone Occurrence of tin(II) Stability
The financial supports from the NKFIH-OTKA (No K115913 and K115784) and Hungarian-Croatian S&T (No TÉT_16-1-2016-0002) grants are acknowledged.
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