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Hyperfine Interactions

, 239:32 | Cite as

119Sn Mössbauer study of Sn-containing radiopharmaceutical kits

  • E. Kuzmann
  • Z. Homonnay
  • Sz. Keresztes
  • M. Antalffy
  • J. Környei
Article
  • 20 Downloads
Part of the following topical collections:
  1. Proceedings of the 4th Mediterranean Conference on the Applications of the Mössbauer Effect (MECAME 2018), Zadar, Croatia, 27–31 May 2018

Abstract

Sn-containing radiopharmaceutical kits, MULTIBONE (composed from stannous chloride dihydrate and EDTMP (ethylene-diamine-tetramethylene phosphonate) and PHYTON (composed from stannous chloride dihydrate and PHYTATE (myo-inositol-hexaphosphate ester) kits, to be used for monitoring in liver tumor therapy, were characterized by 119Sn Mössbauer spectroscopy and XRD measurements. XRD revealed the amorphous nature of the Sn-containing compounds. 80 K 119Sn Mössbauer spectra of both compounds indicated the dominant presence of tin(II) state with characteristic Mössbauer parameters of δ = 3.12 ± 0.01 mms−1 and Δ = 1.84 ± 0.02 mms−1 as well as δ = 3.01 ± 0.01 ± 0.01 mms−1 and Δ = 1.73 ± 0.02 mms−1 for Sn-PHYTATE and Sn-EDTMP, respectively. The occurrence of tin(IV) in Sn-MULTIBONE was as low as measured in the precursor stannous chloride dihydrate (∼3%).

Keywords

119Sn Mössbauer spectroscopy Pharmaceutical kits Sn-Phytate Sn-Multibone Occurrence of tin(II) Stability 

Notes

Acknowledgements

The financial supports from the NKFIH-OTKA (No K115913 and K115784) and Hungarian-Croatian S&T (No TÉT_16-1-2016-0002) grants are acknowledged.

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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Institute of ChemistryEötvös Loránd UniversityBudapestHungary
  2. 2.Institute of Isotopes Co., Ltd.BudapestHungary

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