Hyperfine Interactions

, Volume 219, Issue 1–3, pp 57–61 | Cite as

Biodegradation of magnetic nanoparticles evaluated from Mössbauer and magnetization measurements

  • I. Mischenko
  • M. Chuev
  • V. Cherepanov
  • M. Polikarpov
  • V. Panchenko
Article

Abstract

In order to extract a quantitative information about characteristics of the magnetic nanoparticles injected into a living organism it is necessary to define a model of the magnetic dynamics for fitting self-consistently the whole set of the experimental data, specifically, the evolution of Mössbauer spectral shape with temperature and external magnetic field as well as the magnetization curves. We have developed such a model and performed such an analysis of the temperature- and magnetic field-dependent spectra and magnetization curves of nanoparticles injected into mice. This allowed us to reliably evaluate changes in the characteristics of the residual particles and their chemical transformation to paramagnetic ferritin-like forms in different mouse organs as a function of time. Actually, the approach makes it possible to quantitatively characterize biodegradation and biotransformation of magnetic nanoparticles delivered in a body.

Keywords

Magnetic nanoparticles Magnetic dynamics Biodegradation 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Chuev, M.A., Hesse, J.: Non-equilibrium magnetism of single-domain particles for characterization of magnetic nanomaterials. In: Tamayo, K.B. (ed.) Magnetic Properties of Solids, pp. 1–104. Nova Science Publishers, New York (2009)Google Scholar
  2. 2.
    Papaefthymiou, G.C.: The Mössbauer and magnetic properties of ferritin cores. Biochim. Biophys. Acta 1800, 886–897 (2010)CrossRefGoogle Scholar
  3. 3.
    Chuev, M.A., Cherepanov, V.M., Deyev, S.M., Mischenko, I.N., Nikitin, M.P., Polikarpov, M.A., Panchenko, V.Y.: Interpretation of the Mössbauer spectra of the magnetic nanoparticles in mouse spleen. AIP Conf. Proc. 1311, 322–328 (2010)ADSCrossRefGoogle Scholar
  4. 4.
    Jones, D.H., Srivastava, K.K.P.: Many-state relaxation model for the Mössbauer spectra of superparamagnets. Phys. Rev. B 34, 7542–7548 (1986)ADSCrossRefGoogle Scholar
  5. 5.
    Chuev, M.A.: Multi-level relaxation model for describing the Mössbauer spectra of single-domain particles in the presence of quadrupolar hyperfine interaction. J. Phys.: Condens. Matter 23, 426003 (11pp) (2011)ADSCrossRefGoogle Scholar
  6. 6.
    Chuev, M.A.: Multilevel relaxation model for describing the Mössbauer spectra of nanoparticles in a magnetic field. JETP 114, 609–630 (2012)ADSCrossRefGoogle Scholar
  7. 7.
    Chuev, M.A.: On the thermodynamics of antiferromagnetic nanoparticles by example of Mössbauer spectroscopy. JETP Lett. 95, 295–301 (2012)ADSCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • I. Mischenko
    • 1
  • M. Chuev
    • 1
  • V. Cherepanov
    • 2
  • M. Polikarpov
    • 2
  • V. Panchenko
    • 2
  1. 1.Institute of Physics and TechnologyRussian Academy of SciencesMoscowRussia
  2. 2.National Research Centre “Kurchatov Institute”MoscowRussia

Personalised recommendations