Hyperfine Interactions

, Volume 222, Issue 1–3, pp 1–13 | Cite as

NQR investigation and characterization of cocrystals and crystal polymorphs

  • Janez SeligerEmail author
  • Veselko Žagar
  • Tetsuo Asaji


The application of 14N NQR to the study of cocrystals and crystal polymorphs is reviewed. In ferroelectric and antiferroelectric organic cocrystals 14N NQR is used to determine proton position in an N-H...O hydrogen bond and proton displacement below TC. In cocrystal isonicitinamide – oxalic acid (2:1) 14N NQR is used to distinguish between two polymorphs and to determine the type of the hydrogen bond (N...H-O). The difference in the 14N NQR spectra of cocrystal formers and cocrystal is investigated in case of carbamazepine, saccharin and carbamazepine - saccharin (1:1). The experimental resolution allows an unambiguous distinction between the 14N NQR spectrum of the cocrystal and the 14N NQR spectra of the cocrystal formers. The possibility of application of NQR and double resonance for the determination of the inhomogeneity of the sample and for the study of the life time of an unstable polymorph is discussed.


Nuclear quadrupole interaction Cocrystal Hydrogen bond Ferroelectric API 


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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  1. 1.Jozef Stefan InstituteLjubljanaSlovenia
  2. 2.Faculty of Mathematics and PhysicsUniversity of LjubljanaLjubljanaSlovenia
  3. 3.EN-FIST Centre of ExcellenceLjubljanaSlovenia
  4. 4.Department of Chemistry, College of Humanities and SciencesNihon UniversityTokyoJapan

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