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Environmentally responsive hydrogels for repair of cardiovascular tissue

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Abstract

Cardiovascular diseases (CVDs) pose a serious threat to human health, which are characterized by high disability and mortality rate globally such as myocardial infarction (MI), atherosclerosis, and heart failure. Although stem cells transplantation and growth factors therapy are promising, their low survival rate and loss at the site of injury are major obstacles to this therapy. Recently, the development of hydrogel scaffold materials provides a new way to solve this problem, which have shown the potential to treat CVD. Among these scaffold materials, environmentally responsive hydrogels have great prospects in repairing the microenvironment of cardiovascular tissues and vascular regeneration. They provide a new method for the treatment of cardiovascular tissue repair and space-time control for the release of various therapeutic drugs, including small-molecule drugs, growth factors, and stem cells. Herein, this article reviews the occurrence and current treatment of CVD, as well as the repair of cardiovascular injury by several environmental responsive hydrogels systems currently used, mainly focusing on the delivery of growth factors or the application of cell therapy to revascularization. In addition, we will also discuss the enormous potential and personal perspectives of environmentally responsive hydrogels in cardiovascular repair.

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Funding

This study was funded by the Fostering Talents of National Natural Science Foundation of China and Henan Province (No. U1504310), Key Scientific Research Projects of Higher Education Institutions in Henan Province (No. 16A430030), Key Project and Special Foundation of Research, Development and Promotion in Henan Province (No. 182102310076), Top Doctor Program of Zhengzhou University (No. 32210475), and the Joint Fund for Fostering Talents of NCIR-MMT & HNKL-MMT (No. MMT2017-01).

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  1. Shuaimeng Guan, Jiankang Li & Kun Zhang

    Present address: School of Life Science, Zhengzhou University, Zhengzhou, 450000, People’s Republic of China

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    Jingan Li

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Guan, S., Li, J., Zhang, K. et al. Environmentally responsive hydrogels for repair of cardiovascular tissue. Heart Fail Rev 26, 1273–1285 (2021). https://doi.org/10.1007/s10741-020-09934-y

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