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Left ventricular noncompaction, morphological, and clinical features for an integrated diagnosis

  • Francesco NegriEmail author
  • Antonio De Luca
  • Enrico Fabris
  • Renata Korcova
  • Carlo Cernetti
  • Chrysanthos Grigoratos
  • Giovanni Donato Aquaro
  • Gaetano Nucifora
  • Paolo G. Camici
  • Gianfranco Sinagra
Article

Abstract

The presence of myocardial noncompaction (NC), regardless of the criterion used, does not identify cardiomyopathy per se. The distinction between a morphological variant and the presence of an NC cardiomyopathy is challenging. However, thanks to larger cohorts of patients and longer periods of follow-up, better clinical characterization and prognostic evaluation are becoming available. Indeed, the physician is required to integrate the evidence of NC with the clinical history of the patient, which is supplemented by necessary advanced instrumental investigations before a definite diagnosis of NC cardiomyopathy can be made. Therefore, we extensively revised the current literature in order to help the clinicians to identify clinical features which are pivotal supporting diagnostic element for the correct recognition of Left ventricular noncompaction cardiomyopathy and thus highlighting the difference between a form of cardiomyopathy and a mere intraventricular hypertrabeculation.

Keywords

Left ventricular noncompaction Cardiomyopathy Echocardiography Cardiac magnetic resonance Late gadolinium enhancement Genetics 

Notes

Acknowledgments

This study was supported by the CRTrieste, FINCANTIERI, and GENERALI Foundations to Heart Muscle Diseases Research at Cardiovascular Department, University Hospital of Trieste.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Francesco Negri
    • 1
    Email author return OK on get
  • Antonio De Luca
    • 1
  • Enrico Fabris
    • 1
  • Renata Korcova
    • 1
  • Carlo Cernetti
    • 2
  • Chrysanthos Grigoratos
    • 3
    • 4
  • Giovanni Donato Aquaro
    • 3
  • Gaetano Nucifora
    • 5
    • 6
  • Paolo G. Camici
    • 7
  • Gianfranco Sinagra
    • 1
  1. 1.Cardiovascular Department, Cardiomyopathy CenterAzienda Sanitaria Universitaria Integrata di TriesteTriesteItaly
  2. 2.Head of Cardio-Neuro-Vascular Department Ca’ Foncello and San Giacomo Hospital Azienda N 2TrevisoItaly
  3. 3.Fondazione G. Monastiero CNR-Regione ToscanaPisaItaly
  4. 4.Scuola Superiore Sant’AnnaInstitute of Life SciencesPisaItaly
  5. 5.Northwest Heart Centre, Wythenshawe HospitalManchester University NHS Foundation TrustManchesterUK
  6. 6.Flinders University, Bedford ParkAdelaideAustralia
  7. 7.Vita-Salute University and San Raffaele HospitalMilanItaly

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