Heart Failure Reviews

, Volume 24, Issue 2, pp 189–197 | Cite as

Atrial fibrillation in hypertrophic cardiomyopathy: prevalence, clinical impact, and management

  • Lohit GargEmail author
  • Manasvi Gupta
  • Syed Rafay Ali Sabzwari
  • Sahil Agrawal
  • Manyoo Agarwal
  • Talha Nazir
  • Jeffrey Gordon
  • Babak Bozorgnia
  • Matthew W. Martinez


Hypertrophic cardiomyopathy (HCM) is the most common hereditary cardiomyopathy characterized by left ventricular hypertrophy and spectrum of clinical manifestation. Atrial fibrillation (AF) is a common sustained arrhythmia in HCM patients and is primarily related to left atrial dilatation and remodeling. There are several clinical, electrocardiographic (ECG), and echocardiographic (ECHO) features that have been associated with development of AF in HCM patients; strongest predictors are left atrial size, age, and heart failure class. AF can lead to progressive functional decline, worsening heart failure and increased risk for systemic thromboembolism. The management of AF in HCM patient focuses on symptom alleviation (managed with rate and/or rhythm control methods) and prevention of complications such as thromboembolism (prevented with anticoagulation). Finally, recent evidence suggests that early rhythm control strategy may result in more favorable short- and long-term outcomes.


Atrial fibrillation Hypertrophic cardiomyopathy Treatment Antiarrhythmic agents 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Supplementary material

10741_2018_9752_MOESM1_ESM.docx (126 kb)
Supplementary Table 1 (DOCX 126 kb)


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Authors and Affiliations

  1. 1.Division of CardiologyLehigh Valley Health NetworkAllentownUSA
  2. 2.Maulana Azad Medical CollegeDelhiIndia
  3. 3.Division of CardiologyBrown UniversityProvidenceUSA
  4. 4.Department of Internal MedicineThe University of Tennessee Health Science CenterMemphisUSA

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