Heart Failure Reviews

, Volume 24, Issue 1, pp 91–100 | Cite as

Cardio-oncology: a new and developing sector of research and therapy in the field of cardiology

  • Peggy M. KostakouEmail author
  • Nikos T. Kouris
  • Vassilios S. Kostopoulos
  • Dimitrios S. Damaskos
  • Christoforos D. Olympios


Cardio-oncology is a new field of interest in cardiology that focuses on the detection, monitoring, and treatment of cardiovascular disease occurring as a side effect of chemotherapy and radiotherapy. Both cancer treatment modalities can cause cardiac dysfunction, a major cause of morbidity and mortality in the oncologic population. It is necessary to periodically monitor cancer patients under treatment, especially those receiving anthracyclines and trastuzumab (monoclonal antibody), using mainly 3D echocardiography to calculate left ventricular ejection fraction and to estimate myocardial deformation. Additionally, measuring various biomarkers, such as natriuretic peptides, could facilitate early identification and appropriate response to potential cardiotoxicity. In this regard, cardiological assessment before starting cancer treatment is essential and should be continued throughout, since cardiac dysfunction can occur at any time, even several years after therapy onset. High-risk individuals, in particular, should receive a detailed management plan designed in collaboration between an oncology and a cardiology specialist. If heart failure develops, even in the absence of overt clinical symptoms, standard heart treatment is to be followed and causal agent discontinued if possible. One important question is whether and when to stop cardiac medication in case of heart dysfunction reversal, after completion of cancer treatment. Further cardio-oncology evolution can lead to a deeper understanding of the adverse mechanisms and effects causing heart failure, as well as the development of personalized treatment regimens in order to limit cardiotoxicity.


Cardiotoxicity Cancer Heart failure Echocardiography Strain 



Angiotensin-converting enzyme


Global longitudinal strain


Heart failure


Left ventricular


Left ventricular ejection fraction


Magnetic resonance imaging


Vascular endothelial growth factors


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Peggy M. Kostakou
    • 1
    Email author
  • Nikos T. Kouris
    • 1
  • Vassilios S. Kostopoulos
    • 1
  • Dimitrios S. Damaskos
    • 1
  • Christoforos D. Olympios
    • 1
  1. 1.Cardiology DepartmentGeneral Hospital of Elefsina ‘Thriassio’AthensGreece

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