Heart Failure Reviews

, Volume 20, Issue 3, pp 273–282 | Cite as

Translating thyroid hormone effects into clinical practice: the relevance of thyroid hormone receptor α1 in cardiac repair

  • Constantinos Pantos
  • Iordanis Mourouzis


Thyroid hormone (TH) appears to have a critical role in cardiac repair after injury beyond its role in development and metabolism homeostasis. This unique action is due to the fact that TH effect on the heart is shown to be differentiated depending on its administration on injured or healthy myocardium. Thus, TH can limit ischemia–reperfusion injury via a fine balance between pro-apoptotic and pro-survival signaling pathways. This response is thyroid hormone receptor (TRα1) dependent. Furthermore, an interaction between stress-induced growth kinase signaling and TRα1 is shown to occur and determine postischemic remodeling and cardiac recovery depending on the availability of TH. This new evidence is consistent with clinical observations showing the cardioprotective effect of TH treatment in cardiac surgery, transplantation and heart failure. TH and/or thyroid analogs may be novel agents in treating heart diseases.


Myocardial ischemia Heart failure Cardiac transplantation Thyroid hormone Thyroid hormone receptor α1 



The described work was partly supported by Greek Secretariat of Research and Development (ESPA SYNERGASIA 09ΣΥΝ-21-965).

Conflict of interest

Dr. Constantinos Pantos and Dr. Iordanis Mourouzis have no conflict of interest or financial ties to disclose.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of PharmacologyUniversity of AthensAthensGreece

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