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Heart Failure Reviews

, 15:103 | Cite as

Cardiomyopathy in Duchenne muscular dystrophy: pathogenesis and therapeutics

  • Abdallah Fayssoil
  • Olivier Nardi
  • David Orlikowski
  • Djillali Annane
Article

Abstract

Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder caused by the absence of dystrophin, a sarcolemmal protein which links the cytoskeleton to the extracellular matrix by interacting with a large number of proteins. Heart failure is a classic complication of this disease. The authors review the pathogenesis and therapeutics of cardiac involvement in DMD.

Keywords

Duchenne Dystrophin Heart failure ACE inhibitors Beta-blockers Experimental therapies 

Notes

Acknowledgments

Thanks to Talia Ben-Jacob, MD, Cooper University hospital (Camden, New Jersey) for the rereading of this manuscript.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Abdallah Fayssoil
    • 1
  • Olivier Nardi
    • 2
  • David Orlikowski
    • 2
  • Djillali Annane
    • 2
  1. 1.University of Medicine and Dentistry of New JerseyCamdenUSA
  2. 2.Intensive Care UnitRaymond Poincaré Hospital, AP-HPGarchesFrance

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