Heart Failure Reviews

, Volume 13, Issue 3, pp 355–365 | Cite as

Hypertension, RAS, and gender: what is the role of aminopeptidases?

  • María Jesús Ramírez-Expósito
  • José Manuel Martínez-Martos
Article

Abstract

Hypertension is the major risk factor for coronary heart disease, stroke, and renal disease. Also, it is probably the most important risk factor for peripheral vascular disease and vascular dementia. Although hypertension occurs in both men and women, gender differences have been observed. However, whether sex hormones are responsible for the observed gender-associated differences in arterial blood pressure, and which is their mechanism of action, remains unclear. Local and circulating renin–angiotensin systems (RAS) are examples of systems that may be involved in the pathogenesis of hypertension. Classically, angiotensin II (Ang II) has been considered as the effector peptide of the RAS, but Ang II is not the only active peptide. Several of its degradation products, including angiotensin III (Ang III) and angiotensin IV (Ang IV) also possess biological functions. These peptides are formed via the activity of several aminopeptidases. This review will briefly summarize what is known about gender differences in RAS-regulating aminopeptidase activities, their relationship with sex hormones, and their potential role in controlling blood pressure acting through local and circulating RAS.

Keywords

RAS Angiotensinase Gender differences Sex hormones 

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • María Jesús Ramírez-Expósito
    • 1
  • José Manuel Martínez-Martos
    • 1
  1. 1.Experimental and Clinical Physiopathology Research Group, Department of Health Sciences/Physiology, Faculty of Experimental and Health SciencesUniversity of JaénJaenSpain

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