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Heart Failure Reviews

, Volume 12, Issue 3–4, pp 261–266 | Cite as

Connexin 43 in ischemic pre- and postconditioning

  • Rainer Schulz
  • Kerstin Boengler
  • Andreas Totzeck
  • Yukun Luo
  • David Garcia-Dorado
  • Gerd HeuschEmail author
Article

Abstract

Connexin 43 (Cx43) is the predominant protein forming gap junctions and non-junctional hemichannels in ventricular myocardium, but Cx43 is also localized at the inner membrane of cardiomyocyte mitochondria. In cardiomyocytes, Cx43 is involved in the formation of reactive oxygen species, which are central to the signal transduction cascade of ischemic preconditioning’s protection. Accordingly, genetically-induced or age-related loss of Cx43 abolishes infarct size reduction by ischemic preconditioning. Similarly, mitochondrial import inhibition of Cx43 completely blocks infarct size reduction by pharmacological preconditioning with diazoxide. In contrast to its importance for preconditioning-induced cardioprotection, Cx43 is not important for infarct size reduction by ischemic postconditioning. In summary, Cx43––especially Cx43 localized in mitochondria––appears to be one key element of the signal transduction cascade of the protection by preconditioning.

Keywords

Connexin 43 Ischemic preconditioning Ischemic postconditioning Signal transduction 

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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Rainer Schulz
    • 1
  • Kerstin Boengler
    • 1
  • Andreas Totzeck
    • 1
  • Yukun Luo
    • 1
  • David Garcia-Dorado
    • 2
  • Gerd Heusch
    • 1
    Email author
  1. 1.Institut für Pathophysiologie, Zentrum für Innere MedizinUniversitätsklinikum EssenEssenGermany
  2. 2.Servicio de CardiologiaHospital Universitari Vall D’HebronBarcelonaSpain

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