Journal of Molecular Histology

, Volume 44, Issue 1, pp 37–45 | Cite as

Increased expression of actin filament-stabilizing protein tropomyosin after rat traumatic brain injury

Original Paper


Tropomyosin (TM), is a coiled-coil dimmer which modulates actin filament properties, has been implicated in the control of actin filament dynamics during cell migration, morphogenesis, and cytokinesis. However, the expressions and possible functions of tropomyosin in central nervous system (CNS) lesion remain unknown. In this study, we found the expression of tropomyosin gradually increased in rat brains subjected to traumatic brain injury (TBI). Double immunofluorescence staining showed tropomyosin was expressed in neurons and reactive astrocytes following TBI but not in quiescent astrocytes in normal brains. Furthermore, we detected that proliferating cell nuclear antigen (PCNA) had the co-localization with GFAP, and tropomyosin. In conclusion, this was the first description of tropomyosin expression in rat traumatic brain. Our date suggested that tropomyosin might be involved in the astrocytes proliferation following TBI.


Tropomyosin Traumatic brain injury Astrogliosis Rat 



This study was supported by the National Natural Science Foundation of China (No. 81070992) and A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).


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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Xinmin Wu
    • 1
    • 2
  • Hongran Fu
    • 2
  • Feihui Zou
    • 2
  • Wei Jin
    • 2
  • Ting Xu
    • 2
  • Peipei Gong
    • 2
  • Jian Xu
    • 3
  • Yaohua Yan
    • 2
  • Gang Cui
    • 2
  • Kaifu Ke
    • 2
  • Yilu Gao
    • 2
  • Chunfeng Liu
    • 4
  • Yongjin Pan
    • 2
  1. 1.The Department of NeurologySecond Affiliated Hospital of Soochow UniversitySuzhouChina
  2. 2.Department of NeurologyAffiliated Hospital of Nantong UniversityNantongPeople’s Republic China
  3. 3.The Department of PsychiatryThe Fourth People’s Hospital of NantongNantongPeople’s Republic China
  4. 4.The Department of NeurologySecond Affiliated Hospital of Soochow UniversitySuzhouChina

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