Journal of Molecular Histology

, Volume 44, Issue 1, pp 83–90 | Cite as

The effects of topical treatment with curcumin on burn wound healing in rats

  • Mustafa KulacEmail author
  • Cevat Aktas
  • Feti Tulubas
  • Ramazan Uygur
  • Mehmet Kanter
  • Mustafa Erboga
  • Mehmet Ceber
  • Birol Topcu
  • Oguz Aslan Ozen
Original Paper


The present study was designed to determine the role of topical treatment with curcumin (Cur) on burn wound healing in rats. The Wistar-albino rats were randomly allotted into one of three experimental groups: 4th, 8th and 12th day (post burn) and all groups include subgroups which Burn and Burn + Cur. Each group contains 12 animals. Burn wounds were made on the back of rat and Cur was administered topically. At the end of the study, all animals were sacrificed and the wound tissues removed for analyse to biochemical and histopathological changes. There was a significant increase in the hydroxyproline levels in the skin of the Cur groups. Cur treated wounds were found to heal much faster as indicated by improved rates of inflammatory cells, collagen deposition, angiogenesis, granulation tissue formation and epithelialization which were also confirmed by histopathological and biochemical examinations. Our data also indicate that there is a rise in the expression of proliferating cell nuclear antigen in skin tissues of Cur-treated rats in the Burn group. The results clearly substantiate the beneficial effects of the topical application of Cur in the acceleration of wound healing.


Burn wound healing Curcumin PCNA Hydroxyproline Rat 


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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Mustafa Kulac
    • 1
    Email author
  • Cevat Aktas
    • 2
  • Feti Tulubas
    • 3
  • Ramazan Uygur
    • 4
  • Mehmet Kanter
    • 5
  • Mustafa Erboga
    • 6
  • Mehmet Ceber
    • 7
  • Birol Topcu
    • 8
  • Oguz Aslan Ozen
    • 4
  1. 1.Department of Dermatology, Faculty of MedicineNamik Kemal UniversityTekirdagTurkey
  2. 2.Department of Histology and Embryology, Faculty of MedicineNamik Kemal UniversityTekirdagTurkey
  3. 3.Department of Biochemistry, Faculty of MedicineNamik Kemal UniversityTekirdagTurkey
  4. 4.Department of Anatomy, Faculty of MedicineNamik Kemal UniversityTekirdagTurkey
  5. 5.Department of Histology and Embryology, Faculty of MedicineIstanbul Medeniyet UniversityIstanbulTurkey
  6. 6.Department of Histology and Embryology, Faculty of MedicineUniversity of TrakyaEdirneTurkey
  7. 7.Department of Plastic, Reconstructive and Aesthetic Surgery, Faculty of MedicineNamik Kemal UniversityTekirdagTurkey
  8. 8.Department of Biostatistics, Faculty of MedicineNamik Kemal UniversityTekirdagTurkey

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