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Journal of Molecular Histology

, Volume 39, Issue 4, pp 447–457 | Cite as

Neuronal nitric oxide synthase immunopositive neurons in cat claustrum—a light and electron microscopic study

  • Dimka Hinova-Palova
  • Lawrence Edelstein
  • Adrian Paloff
  • Stanislav Hristov
  • Vassil Papantchev
  • Wladimir Ovtscharoff
Original Paper

Abstract

Nitric oxide is a unique neurotransmitter, which participates in many physiological and pathological processes in the organism. Nevertheless there are little data about the neuronal Nitric Oxide Synthase immunoreactive (nNOS-ir) neurons and fibers in the dorsal claustrum (DC) of a cat. In this respect the aims of this study were: (1) to demonstrate nNOS-ir in the neurons and fibers of the DC; (2) to describe their light microscopic morphology and distribution; (3) to investigate and analyze the ultrastructure of the nNOS-ir neurons, fibers and synaptic terminals; (4) to verify whether the nNOS-ir neurons consist a specific subpopulation of claustral neurons; (5) to verify whether the nNOS-ir neurons have a specific pattern of organization throughout the DC. For demonstration of the nNOS-ir the Avidin-Biotin-Peroxidase Complex method was applied. Immunopositive for nNOS neurons and fibers were present in all parts of DC. On the light microscope level nNOS-ir neurons were different in shape and size. According to the latter they were divided into three groups—small (with diameter under 15 μm), medium-sized (with diameter from 16 to 20 μm) and large (with diameter over 21 μm). Some of nNOS-ir neurons were lightly-stained while others were darkly-stained. On the electron microscope level the immunoproduct was observed in neurons, dendrites and terminal boutons. Different types of nNOS-ir neurons differ according to their ultrastructural features. Three types of nNOS-ir synaptic boutons were found. As a conclusion we hope that the present study will contribute to a better understanding of the functioning of the DC in cat and that some of the data presented could be extrapolated to other mammals, including human.

Keywords

Cat Claustrum Nitric oxide Nitric oxide synthase NO NOS Light microscopy Ultrastructure 

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Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Dimka Hinova-Palova
    • 1
  • Lawrence Edelstein
    • 2
  • Adrian Paloff
    • 1
  • Stanislav Hristov
    • 3
  • Vassil Papantchev
    • 1
  • Wladimir Ovtscharoff
    • 1
  1. 1.Department of Anatomy and HistologyMedical UniversitySofiaBulgaria
  2. 2.Del MarUSA
  3. 3.Deparment of Forensic MedicineMedical UniversitySofiaBulgaria

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