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Journal of Molecular Histology

, Volume 37, Issue 5–7, pp 183–188 | Cite as

Clusterin and DNA repair: a new function in cancer for a key player in apoptosis and cell cycle control

  • B. Shannan
  • M. Seifert
  • D. A. Boothman
  • W. Tilgen
  • J. ReichrathEmail author
Original Paper

Abstract

The glycoprotein clusterin (CLU), has two known isoforms generated in human cells. A nuclear form of CLU protein (nCLU) is pro-apoptotic, while a secretory form (sCLU) is pro-survival. Both forms are implicated in various cell functions, including DNA repair, cell cycle regulation, and apoptotic cell death. CLU expression has been associated with tumorigenesis and the progression of various malignancies. In response to DNA damage, cell survival can be enhanced by activation of DNA repair mechanisms, while simultaneously stimulating energy-expensive cell cycle checkpoints that delay the cell cycle progression to allow more time for DNA repair. This review summarizes our current understanding of the role of clusterin in DNA repair, apoptosis, and cell cycle control and the relevance.

Keywords

Clusterin DNA repair Double strand break Apoptosis Cell cycle control 

Notes

Acknowledgement

This work was supported in part by grant DE-FG02–06ER64186 to DAB.

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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • B. Shannan
    • 1
  • M. Seifert
    • 1
  • D. A. Boothman
    • 2
  • W. Tilgen
    • 1
  • J. Reichrath
    • 1
    Email author
  1. 1.Department of DermatologyThe Saarland University HospitalHomburg/Saar Germany
  2. 2.Department of Oncology, Laboratory of Molecular Stress ResponsesUniversity of Texas Southwestern Medical CenterDallasUSA

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