An agent-based simulation model to study accountable care organizations
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Creating accountable care organizations (ACOs) has been widely discussed as a strategy to control rapidly rising healthcare costs and improve quality of care; however, building an effective ACO is a complex process involving multiple stakeholders (payers, providers, patients) with their own interests. Also, implementation of an ACO is costly in terms of time and money. Immature design could cause safety hazards. Therefore, there is a need for analytical model-based decision-support tools that can predict the outcomes of different strategies to facilitate ACO design and implementation. In this study, an agent-based simulation model was developed to study ACOs that considers payers, healthcare providers, and patients as agents under the shared saving payment model of care for congestive heart failure (CHF), one of the most expensive causes of sometimes preventable hospitalizations. The agent-based simulation model has identified the critical determinants for the payment model design that can motivate provider behavior changes to achieve maximum financial and quality outcomes of an ACO. The results show nonlinear provider behavior change patterns corresponding to changes in payment model designs. The outcomes vary by providers with different quality or financial priorities, and are most sensitive to the cost-effectiveness of CHF interventions that an ACO implements. This study demonstrates an increasingly important method to construct a healthcare system analytics model that can help inform health policy and healthcare management decisions. The study also points out that the likely success of an ACO is interdependent with payment model design, provider characteristics, and cost and effectiveness of healthcare interventions.
KeywordsAgent-based model Health policy simulation Accountable care organization Congestive heart failure Payment model
The current health system in the United States lacks mechanisms and incentives for providers to control rapidly rising healthcare costs and improve quality of care . Hence, an idea was proposed in 2007 of an accountable care organization (ACO), a group of providers who accept greater accountability for total costs and quality of care [2, 3]; this has been widely discussed since it was outlined in the Patient Protection and Affordable Care Act  in 2010. The Centers for Medicare & Medicaid Services (CMS) have established a Medicare Shared Savings Program to create ACOs implementing shared saving payment models . In addition, many private insurers and healthcare organizations have launched or will launch their ACO demonstrations in the near future .
However, an ACO could implement a broad range of delivery and payment models (capitation, bundled payment, shared saving) ; it is unclear how ACOs should be structured and implemented  to deliver high-quality care and control spending. Meanwhile, an ACO demonstration is costly in terms of time and money and could cause safety hazards because of immature design. Therefore, the design and implementation of ACOs are complex and risky, and there is a need for predictive analytics tools that can predict future outcomes of different ACO models and generate recommendations based on goals set by policymakers.
Industrial and Systems Engineering (ISE) methods have the potential to address this need. However, traditional ISE approaches are facing challenges in modeling some important features of an ACO, which is composed of multiple interacting individual stakeholders from multiple sectors–including payers, providers, and patients–who are working to maximize their own interests. Consequently, the Agency for Healthcare Research & Quality (AHRQ) has called for methodologies that can incorporate different objectives and behaviors of multiple interacting stakeholders from different sectors into the model and make optimal recommendations for the overall system ; AHRQ has identified the methodologies as a critical area of ISE research in healthcare.
The main contribution of this article is that an agent-based model was developed to address the needs of predictive analytics for ACOs from a cross-sectoral point of view. By combining different agents’ varying goals and behaviors from their vantage points in a system model, the analysis reveals new, integrated insights to help inform health policy and healthcare management decisions. A simulation study that analyzes ACOs aiming to deliver better care for congestive heart failure (CHF) was also developed to demonstrate the use of the agent-based model. CHF was selected in the model because it is the leading cause for hospitalization and high healthcare costs for elders . In addition, multiple meta-analyses of clinical trials have shown that interventions of disease management programs could reduce CHF readmission rates and improve other health outcomes, including survival rates and quality of life [11, 12]. Therefore, payers and ACOs have the potential to create incentives and mechanisms to facilitate the adoption and implementation of this evidence-based care. The goal of the agent-based simulation model is not to substitute an ACO pilot program but to facilitate ACO design and implementation processes by providing analytic supports for decision-makers to make informed decisions.
A shared saving payment model for the ACOs was examined in the agent-based model because it is a popular payment model used in the CMS Shared Savings Program  and many other current and planned ACO demonstrations. Furthermore, it serves as an important bridge between the traditional fee-for-service model and more fundamental risk-sharing payment models, such as episode-based payment. Under shared saving payment, if a group of providers can control or reduce the total healthcare costs of a patient population while meeting quality measures, a portion of the saving will be awarded to the providers.
In this paper, Section 2 describes the agent-based model developed and a simulation study to demonstrate the model. Section 3 presents the results of the simulation study. A baseline analysis was conducted to compare the performance of an ACO health network and a controlled health network. In addition, multiple scenario analyses were conducted to examine the impacts of payment model designs and provider characteristics on the outcome measures.
In this chapter, the agent-based model developed to provide predictive analytics for ACOs is described, followed by the modeling settings of the simulation study for CHF patients. Section 2.1 briefly introduces the methodology of agent-based modeling and its advantages to model ACOs. Section 2.2 describes the framework of the agent-based model and the designs of each type of agent, including agent’s objectives, characteristics, behaviors, and how an agent interacts with other agents. Section 2.3 provides a gain and cost analysis from different agents’ perspectives in order to model agent decision-making. Section 2.4 discusses the configurations of the simulation run to demonstrate the model.
2.1 Agent-based modeling
Agent-based modeling (ABM) can be viewed as a mindset rather than a specific modeling technique. ABM describes a complex system from the bottom-up perspective and models it as a collection of multiple autonomous agents who have their own objectives, behaviors, and interactions with other agents and the environment. As in the real world, global behaviors and trends emerge from the behavior of and interactions between individual agents [13, 14].
ABM can model individual behaviors of each stakeholder in an ACO and their dynamic interactions. This is a limitation and difficulty of traditional equation-based or discrete event modeling approaches. Because providing coordinated care is an essential part of an ACO, the ability to model agent collaborations and communications is a required function for an ACO model. The structure of ABM makes it easy to define dynamic agent interactions through functions such as message passing and agent networks.
Because ABM does not require predefined aggregate level flow and structure (as in System Dynamics), it is more flexible to expand through adding agent behaviors, interaction rules, and learning capacity. In addition, working as a platform, ABM can incorporate other modeling techniques. For example, it can apply artificial intelligence to model agent behavior changes and can incorporate stochastic process models to simulate agent internal state transitions. Furthermore, because ABM models the system from the individual agent level, it can take advantage of the increasing amount of individual level data.
2.2 Model description
2.2.1 Patient agent
A patient agent denotes a Medicare patient whose age is 65 or older. Each patient agent is characterized by four demographic variables (age, race, gender, and income) and three health condition variables (diabetes, hypertension, and CHF). These variables were the key factors that have impacts on CHF disease progression and healthcare utilization [15, 16, 17, 18].
The CHF-related hospitalization was defined as a hospitalization in which CHF is listed in any of its first seven diagnoses. Because this model targets CHF care, non–CHF-related hospitalizations were not included. In addition, patient agents who have not been diagnosed with diabetes or hypertension are exposed to the risks of developing diabetes or hypertension. Because CHF, diabetes, and hypertension are incurable chronic diseases, once a patient agent develops any of these diseases, he/she will have it for the rest of the simulation.
There is a wide range of cycle time in the CHF modeling literature depending on the measurement needs of the studies [19, 20, 21]. The cycle time in the patient state transition module was set to half a month (15 days) in order to catch hospital readmissions within 30 days since previous discharge. At each cycle, a patient agent will move to other states or remain at the current state according to state transition probabilities, which are determined by the patient agent’s characteristic variables and are adjusted if the patient agent receives the CHF intervention care. The intervention here refers to the comprehensive discharge planning with post-discharge follow-up. More details about it can be found in Phillips et al. .
CHF survival curve
Time since onset of CHF
Transition probability from the CHF-diagnosed state to CHF-related hospitalization
65–74 (age group 1–2)
75–84 (age group 3–4)
> =85 (age group 5)
A patient agent generates inpatient care utilization by moving into the CHF-related hospitalization state. For outpatient care utilization, each patient agent’s regular outpatient visits were modeled as a Poisson process because it is a common approach to modeling patient arrivals [31, 32, 33]. The average number of regular outpatient visits estimated from the literature ranges from eight to ten visits per year [21, 34, 35]. Hence, the parameter of the Poisson process is set to nine visits per year. In addition to regular visits, a follow-up visit after hospital discharge will be scheduled if a patient agent receives the intervention.
2.2.2 Provider agent
The model includes two types of provider agents: the hospital agent and PCP agent; each represents a hospital or a PCP clinic, respectively. The goal of a provider agent is to maximize the utility of the hospital or clinic by deciding whether to conduct the CHF intervention.
The CHF intervention has been demonstrated by a number of clinic trials and meta-analysis studies as able to reduce hospital readmission and mortality rate for CHF patients [11, 12]. The effects of the intervention are modeled by reduction in transition probabilities to the CHF-related hospitalization state and mortality state. The risk reduction was derived from a meta-analysis of CHF interventions . The average risk reduction is 20 % for CHF hospitalization rate and 13 % for CHF mortality rate.
Because most published CHF intervention studies involve collaboration of hospitals and PCPs [11, 12], the full effects of the intervention, it was assumed, could only be achieved when both the hospital where a patient was admitted and the patient’s PCP conducted the intervention. If only one party was conducting the intervention without collaboration with the other party, the intervention could only achieve partial effect.
The third predicting factor, PBC, is a person’s perceived ease or difficulty of performing a particular behavior. As the CHF intervention is a collaborative behavior between hospitals and PCPs, the effects of the intervention are compromised if only one side of the agents conduct the intervention. Therefore, an agent’s perceived ease or difficulty at successfully performing the intervention is influenced by other agents’ behaviors. Hence, the PBC of a provider agent is defined as the perception of the percentage of other agents who are actually conducting the intervention. The process was modeled through agent interactions between hospital agents and PCP agents. An interaction happens when a patient agent is discharged and its hospital agent and PCP agent communicate to update the patient agent’s information and simultaneously to perceive if the other agent is conducting the intervention.
The parameter τ is used to adjust the irrational level of decision-makers. In the demonstrating simulation study, rational decision-making was assumed, so the behavior with higher intention will be performed. The users of the agent-based model can set the parameters to reasonable values for their specific context or learn them empirically.
Last, to examine the impacts of provider characteristics, three hypothetical types of provider agents were defined in the demonstrating simulation study by varying the weights of β = [β1, β2]. The three types of provider agents are profit-oriented with β = [0.8, 0.2], quality-oriented with β = [0.2, 0.8], and neutral with β = [0.5, 0.5]. Scenario analyses with different mixes of these three types of provider agents were conducted and are described in Section 3.
2.2.3 Payer agent
The payer agent hypothetically represents CMS in the model because it is the primary payer for CHF healthcare services. (Note. In the text below, all references to CMS are hypothetical. The study does not reflect the view of the CMS, rather solely the views of the authors.) The CMS will collect cost and quality data, as well as calculate and distribute the shared saving. To calculate the shared saving, two provider agent networks were included: the ACO network and controlled network, each of which serves a patient population with identical patient characteristics. At the end of each year or decision cycle, the total CHF-related healthcare costs per CHF patient will be calculated for each network. The cost difference between these two networks is the saving per CHF patient from the payer’s perspective.
One key parameter of the shared saving payment model is shared saving rate (SSR), which defines the percentage of the total saving that will be awarded to providers. The shared saving per CHF patient is calculated by multiplying the saving per CHF patient with SSR, and the total shared saving is determined by multiplying the shared saving per CHF patient with the number of CHF patients that the ACO network serves.
The total shared saving will then be distributed among hospital agents and PCP agents in the ACO network. The distribution of the shared saving is defined by another key parameter: sharing rate to hospital (SRH), which is the percentage of the total shared saving distributed to hospital agents. Within each type of provider agent, the shared saving was assumed to be distributed equally. If the cost per CHF patient of the ACO network is higher than that of the controlled network, there will be no saving.
2.3 Healthcare costs
The cost analysis was conducted from different agents’ perspectives. The cost for the payer agent representing CMS is the reimbursement paid to providers for CHF-related services plus the shared saving. For CHF-related hospitalization, the AHRQ’s estimation  is used for costs of hospital service, and the physician inpatient cost is estimated to be 18 % of the reimbursement for hospital service [21, 38]. The reimbursement for outpatient visits is determined by the CMS Physician Fee Schedule .
For a hospital agent, negative margins were reported for hospital services of Medicare patients [40, 41]. A −8.4 margin for CHF inpatient services was estimated based on Medicare’s reported reimbursement  and hospital operating costs [43, 44]. For CHF intervention cost, a meta-analysis of CHF interventions  showed that the pooled intervention cost was $108 per patient per month for a usually 6-month-long intervention. The intervention effects were assumed to last for 1 year, which gives us an average cost of $54 per patient per month.
Amount paid by agent, USD (2011)
CHF hospital cost
Inpatient physician fee
Intervention cost per patient per year
2.4 Model implementation
The demonstrating simulation study was implemented using AnyLogic version 6.6 (XJ Technologies, Chicago, IL). In the study, the simulation time was set at 5 simulation years, which is reasonable to test the effects of an ACO demonstration.
The model generates one singlepayer agent hypothetically representing CMS and two networks of provider agents (one ACO network and one controlled network). Both the provider networks are composed of three hospital agents and 15 PCP agents. The ACO network is reimbursed under the shared saving model, and the controlled network is reimbursed under the traditional Medicare fee-for-service (FFS) model. The simulation model generated 10,000 patient agents and randomly assigned them to the ACO networks or the controlled network. For each patient agent, the values of its characteristic variables were assigned on the basis of the joint distribution estimated.
At the end of each simulation year, the payer agent will collect the performance measures for both provider networks, including the payment per CHF patient, the hospital admission rate, and the CHF patient mortality rate. Using those data, the payer agent will calculate and distribute the shared saving to the provider agents in the ACO network. Then, the ACO provider agents will go through the decision-making process to determine if they will conduct the intervention in the next simulation year.
The outputs of each simulation run are the average saving to the payer agent per CHF patient per year, average annual CHF-related admission rate, and CHF patient mortality rate for each provider agent network over 5 simulation years. For each setting of the model input parameters, 500 simulation runs are performed to calculate the mean and 95 % level confidence interval.
3 Simulation results, model validation, and scenario analyses
A baseline analysis was conducted to compare the performance of an ACO health network and a controlled health network. Results below show the baseline model (Section 3.1) and its validation (Section 3.2). Section 3.3 describes the multiple scenario analyses conducted to examine the impacts of payment model designs and provider characteristics on the outcome measures. To examine the influence of provider types on the model outputs, three scenarios were created. The setting of the provider agent type in scenario one is the same with that in the baseline model. In scenario two, all the provider agents are profit-oriented, and in scenario three all the provider agents are quality-oriented. In each scenario, two key parameters of the shared saving payment model, i.e., SSR and SRH, were systematically varied to determine an optimal payment model design. The simulation was rerun for each combination of the values of SSR and SRH in each scenario. A sensitivity analysis was conducted to examine how the uncertainty in other key model inputs influenced the model outputs (Section 3.4).
3.1 Baseline model
In the baseline model, the three hospital agents in the ACO network were a profit-oriented agent, a quality-oriented agent, and a neutral agent. A PCP agent in the ACO network had equal probability of being assigned as one of the three types. The key payment model parameters, SSR and SRH, were set at 0.5 and 0.7, respectively, which means half of the saving was shared with provider agents and 70 % of the shared saving was distributed to hospital agents.
The ACO network performed better in the CHF-related hospitalization rate and annual mortality rate of CHF patients owing to the implementation of evidence-based care. The annual CHF-related hospitalization rate was 63.94 % (95 % CI: 63.74–64.14 %) for the ACO network and 72.46 % (95 % CI: 71.78–73.14 %) for the controlled network. The annual mortality rate of CHF patients was 18.41 % (95 % CI: 18.33–18.49 %) for the ACO network and 19.72 % (95 % CI: 19.64–19.80 %) for the controlled network. From the payer’s or the CMS’s perspective, the average saving after distribution of the shared saving was $765 (95 % CI: $740–790) per CHF patient per year, or a 5.65 % saving compared with the $13,550 (95 % CI: $13,520–13,580) payment per CHF patient in the controlled network. The saving in the ACO network was mainly caused by the reduction in the hospitalization rate.
3.2 Model validation
Because the controlled network provides usual care and does not conduct intervention, its CHF-related hospitalization rate and mortality rate were used to validate the model with the value reported in literature. The mortality rate for CHF patients reported in clinical trials ranges from 15 to 28 % [46, 47, 48]. Note that their sample sizes are usually small, and this could cause larger variation in their estimations. Hence, the mortality rate in the model (19.72 %) is comparable to and within the range of the mortality rates reported in the literature.
Derived from the results of Chen et al.  and Fang et al. , the CHF-related hospitalization rate was estimated around 68.6 %. In addition, the SOLVD study , a large CHF trial whose estimates have been used by many CHF simulation studies, reported an average annual hospitalization rate of 72.9 %. The CHF-related hospitalization rate in the model (72.46 %) is therefore comparable to that reported in the literature.
3.3 Scenarios analyses
To examine the influence of provider types on the model outputs, three scenarios were created. The setting of the provider agent type in scenario one is the same as that in the baseline model. In scenario two, all the provider agents are profit-oriented, and in scenario three, all the provider agents are quality-oriented.
Figure 4 shows that the shared saving to payer (SSP) decreases as SSR increases in all three scenarios. When the payer agent increases the SSR, the resulting additional financial incentives motivate more provider agents to conduct the intervention, causing a reduction in annual CHF-related hospital admission rate (shown in Fig. 5) and in annual CHF patient mortality rate (shown in Fig. 6). The reduction in the CHF-related hospital admission rate then generates more total saving in the system; however, the SSP actually decreases because more saving is shared with the provider agents. Therefore, the payer agent is faced with a trade-off between financial return and quality of care when determining the value of SSR.
This scenario analysis also shows how provider agents in different scenarios respond to changes in SSR. As shown in Fig. 4, given the same SSR, scenario three (all the provider agents are quality-oriented) always yielded higher financial return to the payer agent, followed in order by scenario one and scenario two. The profit-oriented provider agents are most sensitive to the changes in SSR.
The effects of varying SRH given a certain SSR were further examined. Analyzing the payer’s financial return (i.e., SSP by SRH in scenario one), different patterns were observed when the SSR was set at different values. When the SSR was low, there was no clear relationship between SSP and SRH (shown in Fig. 7 when the SSR was set at 0.1). Even if all the saving was distributed to hospital agents (when SRH is 1), it was not enough to cover the intervention cost for the hospital agents and motivate their behavior changes.
When SSR was set to 0.5–0.8, a pattern emerged with a concave shape, whereby the maximal financial return is achieved when the SRH is 0.7 (shown in Fig. 8). Because the effects of the intervention can be fully achieved only when both the hospital agents and PCP agents are conducting it, the 0.7 value of SRH seems to be a good balance point that can motivate both the hospital and PCP agents to conduct the intervention and thus achieve a maximal financial return for the payer agent.
When SSR was high (0.9), Fig. 9 shows a relatively flat trend of SSR when SRH was around 0.5–0.7, and when the SRH was greater than 0.7, SSR decreased as SRH increased. Because the hospital agent had enough financial incentives to conduct the intervention, a clear hospital agent behavior switch was not observed as SRH increased from 0.5 to 0.7. Similar patterns have also been observed in the other two scenarios.
3.4 Sensitivity analysis
After the scenario analyses were conducted on the shared saving payment model and provider types, a sensitivity analysis was conducted to examine how the uncertainty in other key model inputs influenced the model outputs (using SSP). In general, for each testing parameter, a higher value (increased by 20 %) and a lower value (decreased by 20 %) were tested.
How to provide incentives to improve shared accountability in U.S. healthcare systems is a difficult policy issue with a great deal of uncertainties and trade-offs . The CHF agent-based simulation model demonstrated and quantified how different implementations of the ACO and the shared saving payment model can influence provider behavior regarding the evidence-based intervention and therefore generated different financial and quality outcomes. The model can help decision-makers better understand the complexity and risks of ACO design and facilitate more informed decision-making.
Once the SSR is decided, the next step is to determine an SRH value that can motivate both the hospital agents and PCP agents to work together on the CHF intervention. Creating a mechanism to promote cooperation between hospitals and physicians is difficult, and an immature payment model may incite tension and competition between hospitals and physicians . The simulation results have identified different patterns of outcomes by SRH, which can help decision-makers choose the optimal SRH value to maximize the outcomes based on the configuration of SSR.
The model can help analyze how provider types and priorities could influence payment model designs. In the same hypothetical scenario shown in Fig. 11, if all the providers are quality-oriented, CMS can set SSR at 18 % to achieve the same goal of controlling the CHF-related hospital admission rate to 64 %. This setting will generate a $1,200 saving per CHF patient per year instead of a saving of $700 when all the providers are profit-oriented.
This result shows that the payer agent needs to provide different levels of incentives for different types of providers to achieve the same level of quality outcomes. This brings up the problem that the more profit-oriented a provider agent is, the more financial reward he/she will receive from the payer. This problem could be addressed by expanding the payer’s strategies to develop mixed motives to simulate all types of providers , such as aligning the payment with quality requirements, public reporting of quality performance, and initiating education programs to increase awareness of quality of care [53, 54, 55].
The sensitivity analysis showed that the outcomes were most sensitive to the effects of the intervention, followed by the intervention cost. Hence, selecting the cost-effective intervention is critical for the success of an ACO. For broader applications beyond CHF, ACO stakeholders need to wisely choose improvement opportunities to pursue based on their capability and current situations.
There are some limitations to the agent-based model for CHF care. First, the model parameters are based on the best information obtainable. The results reflect a national average trend for Medicare patients. Adjustments should be made when referring to some specific patient demographics, provider characteristics, and geographic locations. Second, the weight for each behavior-predicting factor in the provider decision module is not drawn from a survey of physicians. A national physician’s behavior survey with information to provide the values of these weights was not identified in a literature search. Hence, the users of the model can configure the provider agent parameters on the basis of the characteristics of the providers with whom they are working.
The agent-based simulation model provides predictive analytics and recommendations for decision-makers to make informed decisions on how to design an ACO and its corresponding shared saving payment model, given their current provider and patient population environment, to maximize the desired outcomes.
The agent-based simulation model has identified critical determinants of an optimal design for the payment model that can motivate provider behavior changes to achieve maximum financial and quality outcomes. The model has quantified the trade-off between the payer’s financial return and the quality outcomes, helping decision-makers configure the shared saving model based on their objectives.
The complexity and risks of the ACO model design generate a need for modeling and simulation tools that are flexible, capable, and user-adjustable to facilitate the design and implementation of an ACO model for different disease conditions, payment models, and provider and patient agent characteristics. For future use of the model, users can, based on their situations and objectives, configure the ACO design parameters, generate corresponding patient and provider agents, and then analyze different scenarios and optimize their ACO models.
This study presents the promising application possibilities of ABM, an increasingly important method to support policy and management decision-making in broad and complex healthcare systems. Different from aggregated-level modeling methods, ABM can incorporate various goals and behaviors of individual stakeholders. It is also capable of modeling agent communication and interactions. These advantages make ABM a closer approximation of the real world. Also, because each agent represents a real entity in the health system (such as a physician or a patient), healthcare practitioners are likely to understand and accept the agent-based model. Therefore, the solutions recommended and insights generated for an ACO model design by the agent-based model increase the chance of improving the real health system.
The authors acknowledge the California HealthCare Foundation for a grant to evaluate the Lean Initiative in four California public hospitals to improve performance of CHF care (Grant identification number 08-1889, Principal Investigator Dr. Shinyi Wu). This evaluation project has helped the development of the CHF simulation model presented in the paper. The authors also acknowledge the support from the USC Roybal Center for Health Policy Simulation (Grant number: P30 AG024968), a National Institute on Aging–funded center for developing better models to assess the impact of aging on health, health spending, and healthcare delivery sponsored by the Leonard D. Schaeffer Center for Health Policy and Economics. The authors are grateful for the insights, constructive criticisms, and support from Dr. Carl Kesselman, Dr. Michael Nichol, Dr. Alex Chen, and Dr. Azad Madni of the University of Southern California for this work.
- 1.Newman D (2010) Accountable care organizations and the Medicare Shared Savings Program. Congressional Research ServiceGoogle Scholar
- 4.U.S. House of Representatives (2010) Compilation of patient protection and affordable care act [as amended through May 1 2010]. Washington, DCGoogle Scholar
- 5.Centers for Medicare & Medicaid Services (2011) Medicare shared savings program. https://www.cms.gov/sharedsavingsprogram. Accessed 9 March 2014
- 6.Delbanco SF, Anderson KM, Catherine Eikel Major, Kiser MB, Toner BW (2011) Promising payment reform: risk-sharing with accountable care organizations. The Commonwealth FundGoogle Scholar
- 9.Valdez RS, Ramly E, Brennan PF (2010) Industrial and systems engineering and health care: critical areas of research—final report. Agency for Healthcare Research and Quality, RockvilleGoogle Scholar
- 11.McAlister FA, Stewart S, Ferrua S, McMurray JJ (2004) Multidisciplinary strategies for the management of heart failure patients at high risk for admission: a systematic review of randomized trials. J Am Coll Cardiol 44(4):810–819Google Scholar
- 17.Conen D, Chae CU, Guralnik JM, Glynn RJ (2010) Influence of blood pressure and blood pressure change on the risk of congestive heart failure in the elderly. Swiss Med Wkly 140(13–14):202–208Google Scholar
- 25.Arias E (2010) United States life tables, 2006. National Vital Stat Rep 58(21):1–40Google Scholar
- 31.Kelton WD, Law AM (2000) Simulation modeling and analysis, 3rd edn. McGraw Hill, BostonGoogle Scholar
- 37.AHRQ (2010) 2010 National Healthcare Quality Report. Agency for healthcare research and quality. http://www.ahrq.gov/research/findings/nhqrdr/nhqr10/nhqr10.pdf. Accessed 9 March 2014
- 39.Centers for Medicare & Medicaid Services (2012) Medicare program: physician fee schedule look-up tool. http://www.cms.gov/Medicare/Medicare-Fee-for-Service-Payment/PFSlookup/index.html. Accessed 10 Nov 2012
- 41.AHA (2012) Underpayment by Medicare and Medicaid fact sheet, 2012 updateGoogle Scholar
- 42.Centers for Medicare & Medicaid Services (2011) Medicare program; hospital inpatient prospective payment systems for acute care hospitals and the long-term care hospital prospective payment system and FY 2012 rates; hospitals’ FTE resident caps for graduate medical education payment. http://www.gpo.gov/fdsys/pkg/FR-2011-08-18/pdf/2011-19719.pdf. Accessed 20 March 2014
- 43.Healthcare Financial Management Association (2010) National average costs by department for heart failure and shock. Healthc Financ Manage 64(3):122–123Google Scholar
- 44.Healthcare Financial Management Association (2011) Medicare claims show remarkable variations by region, hospital ownership, and teaching status. Healthc Financ Manage 65(3):142–144Google Scholar
- 45.Rickert J (2012) Do Medicare and Medicaid payment rates really threaten physicians with bankruptcy? HealthAffairs Blog. http://healthaffairs.org/blog/2012/10/02/do-medicare-and-medicaid-payment-rates-really-threaten-physicians-with-bankruptcy/. Accessed 9 March 2014
- 47.Capomolla S, Febo O, Ceresa M, Caporotondi A, Guazzotti G, La Rovere M, Ferrari M, Lenta F, Baldin S, Vaccarini C, Gnemmi M, Pinna G, Maestri R, Abelli P, Verdirosi S, Cobelli F (2002) Cost/utility ratio in chronic heart failure: comparison between heart failure management program delivered by day-hospital and usual care. J Am Coll Cardiol 40(7):1259–1266CrossRefGoogle Scholar
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