Genetica

, Volume 136, Issue 2, pp 295–302 | Cite as

The genetic architecture of complex behaviors: lessons from Drosophila

Article

Abstract

Complex behaviors are affected by multiple interacting loci with individually small and environmentally sensitive effects. Understanding the genetic architecture of behavioral traits begins with identifying the genes regulating these traits, mapping the subset of genetically varying quantitative trait loci (QTLs) in natural populations, and pinpointing the molecular polymorphisms defining QTL alleles. Drosophila brings an impressive toolkit to the challenge of genetically dissecting complex traits: P transposable element mutagenesis to identify genes regulating these traits; artificial selection from natural populations to create extreme trait phenotypes; high resolution mapping to identify positional candidate genes corresponding to QTLs; linkage disequilibrium mapping to identify molecular polymorphism(s) that functionally define QTL alleles; and whole genome transcriptional profiling to postulate networks of interacting genes affecting complex traits. Studies in Drosophila have revealed large numbers of pleiotropic genes that interact epistatically to regulate behavioral traits, and that can have sex- and environment-specific effects. These observations offer valuable lessons for understanding the genetic basis of variation for complex behaviors in other organisms, including humans.

Keywords

P-element mutagenesis QTL mapping Association mapping Microarray profiling Pleiotropy Epistasis 

Abbreviations

QTL

Quantitative trait locus

QTN

Quantitative trait nucleotide

SNP

Single nucleotide polymorphism

cM

centi-Morgan

LD

Linkage disequilibrium

GEI

Genotype by environment interaction

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Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  1. 1.Department of Genetics and The Keck Center for Behavioral BiologyNorth Carolina State UniversityRaleighUSA

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