, Volume 123, Issue 1–2, pp 3–13 | Cite as

Theories of adaptation: what they do and don’t say

  • H. Allen OrrEmail author


Theoretical work on adaptation has lagged behind experimental. But two classes of adaptation model have been partly explored. One is phenotypic and the other DNA sequence based. I briefly consider an example of each – Fisher’s geometric model and Gillespie’s mutational landscape model, respectively – reviewing recent results. Despite their fundamental differences, these models give rise to several strikingly similar results. I consider possible reasons for this congruence. I also emphasize what predictions do and, as important, do not follow from these models.


adaptation adaptive landscape experimental evolution Fisher’s model mutational landscape QTL analysis 


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Copyright information

© Springer 2005

Authors and Affiliations

  1. 1.Department of BiologyUniversity of RochesterRochesterUSA

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