, Volume 122, Issue 1, pp 51–64 | Cite as

Implementing Large-Scale ENU Mutagenesis Screens in North America

  • Amander T. Clark
  • Daniel Goldowitz
  • Joseph S. Takahashi
  • Martha Hotz Vitaterna
  • Sandra M. Siepka
  • Luanne L. Peters
  • Wayne N. Frankel
  • George A. Carlson
  • Janet Rossant
  • Joseph H. Nadeau
  • Monica J. Justice


A step towards annotating the mouse genome is to use forward genetics in phenotype-driven screens to saturate the genome with mutations. The purpose of this article is to highlight the new projects in North America that are focused on isolating mouse mutations after ENU mutagenesis and phenotype screening.

balancer chromosomes Human Genome Project Mouse Genome Project mouse mutagenesis phenotype screens 


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Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Amander T. Clark
    • 1
  • Daniel Goldowitz
    • 2
  • Joseph S. Takahashi
    • 3
  • Martha Hotz Vitaterna
    • 3
  • Sandra M. Siepka
    • 3
  • Luanne L. Peters
    • 4
  • Wayne N. Frankel
    • 5
  • George A. Carlson
    • 6
  • Janet Rossant
    • 7
  • Joseph H. Nadeau
    • 8
  • Monica J. Justice
    • 9
  1. 1.Department of Molecular and Human GeneticsBaylor College of MedicineUSA
  2. 2.Tennessee Mouse Genome CenterUSA
  3. 3.Center for Functional GenomicsNorthwestern UniversityUSA
  4. 4.Center for Mouse Models of HeartLung, Blood and Sleep Disorders, The Jackson LaboratoryUSA
  5. 5.Neuroscience Mutagenesis FacilityThe Jackson LaboratoryUSA
  6. 6.McLaughlin Research Institute for Biomedical SciencesUSA
  7. 7.The Center for Modeling Human DiseaseCanada
  8. 8.Case Western Reserve University/University Hospitals of ClevelandUSA
  9. 9.Department of Molecular and Human GeneticsBaylor College of MedicineUSA

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