Trusting Your Gut, Among Other Things: Digestive Enzyme Secretion, Intuition, and the History of Science
The role of intuition in scientific endeavor is examined through the lens of three philosophers/historians of science—Karl Popper, Thomas Kuhn, and Gerald Holton. All three attribute an important role to imagination/intuition in scientific endeavor. As a case study, the article examines the controversy between the generally accepted Vesicular Sequestration/Exocytosis Model of pancreatic digestive enzyme secretion and an alternative view called the Equilibrium Model. It highlights the intertwining of intuition and reason in the genesis of the Equilibrium Model developed in response to findings that could not readily be explained by the consensus view. It suggests that tacit knowledge/understanding works in conjunction with philosophical and aesthetic presuppositions that function to a greater or lesser extent below awareness. Together they guide judgments about whether falsification has occurred and help frame alternative theories.
KeywordsDigestive enzyme secretion History of science Intuition Unconscious cognition
- Bargh J. A. (Ed.). (2006). Social psychology and the unconscious: The automaticity of higher mental processes. New York: Psychology Press.Google Scholar
- Bendayan M., Roth J., Perrelet A., Orci L. (1980) Pancreatic secretory proteins in subcellular compartments of the rat acinar cell. Journal of Histochemistry and Cytochemistry 28: 149–160Google Scholar
- Damasio A. R. (1994) Descartes’ error: Emotion, reason, and the human brain. G. P. Putnam’s Sons, New YorkGoogle Scholar
- French, R.M., Cleeremans, A. (eds) (2002) Implicit learning and consciousness. Psychology Press, New YorkGoogle Scholar
- Holton G. (1973) Thematic origins of scientific thought: Kepler to Einstein. Harvard University Press, Cambridge, MAGoogle Scholar
- Holton G. (1998) The scientific imagination. Harvard University Press, Cambridge, MAGoogle Scholar
- Isenman L. D. (1997) Towards an understanding of intuition and its importance in scientific endeavor. Perspectives in Biology and Medicine 40: 395–403Google Scholar
- Isenman L. D., Rothman S. S. (1979b) Transpancreatic transport of digestive enzymes. Biochimica Biophysica Acta 585: 321–332Google Scholar
- Isenman, L. D. (1980). Digestive enzyme transport and secretion in the Pancreas. Dissertation, University of CaliforniaGoogle Scholar
- Isenman, L. (2009) Digestive enzyme secretion, intuition, and the history of science: Part II. Foundations of Science, 14. doi:10.1007/s10699-009-9163-1.
- Isenman L. D., Liebow C., Rothman S. S. (1995) Protein transport across membranes: A paradigm in transition. Biochimica Biophysica Acta 1241: 341–370Google Scholar
- Kuhn T. S. (1970) The structure of scientific revolution. University of Chicago Press, ChicagoGoogle Scholar
- Kuhn T. S. (1977) The essential tension. Selected studies in scientific tradition and change. University of Chicago Press, ChicagoGoogle Scholar
- Mangan, B. (2001). Sensations ghost: The non-sensory “fringe” of consciousness. PSYCHE 7 (http://psyche.cs.monash.edu.au/v7/psyche-7-18-mangan.html).
- Polanyi M. (1969) The creative imagination. Psychological Issues 6: 53–70Google Scholar
- Popper K. R. (1959) The logic of scientific discovery. Basic Books, New YorkGoogle Scholar
- Popper K. R. (1963) Conjecture and refutation. Basic Books, New YorkGoogle Scholar
- Rothman S. S., Isenman L. D. (1974) The secretion of digestive enzyme derived from two parallel intracellular pools. American Journal of Physiology 226: 1082–1087Google Scholar
- Rothman S. S. (2002) Lessons from the living cell: The limits of reductionism. McGraw-Hill, New YorkGoogle Scholar