Fish Physiology and Biochemistry

, Volume 35, Issue 3, pp 453–465 | Cite as

Alterations in the brain monoaminergic neurotransmitters of rainbow trout related to naphthalene exposure at the beginning of vitellogenesis

  • Manuel Gesto
  • Adrián Tintos
  • Rosa Álvarez
  • José L. Soengas
  • Jesús M. Míguez
Article

Abstract

The contents of dopamine (DA), noradrenaline (NA), serotonin (5HT), and some related metabolites were studied in different brain regions of rainbow trout at two different stages of sexual maturation (at the beginning of vitellogenesis), after naphthalene (NAP) administration. The effects of NAP varied according to duration of exposure, brain region and vitellogenesis stage of the trout, and were more significant during previtellogenesis. The changes observed in DA metabolism were generally stimulatory after exposure for 3 h, and either stimulatory or inhibitory (depending on the brain regions) after exposure for 3 days to NAP. NA levels were altered by NAP in various brain regions, but only during previtellogenesis. With respect to 5HT, treatment with NAP reduced levels of the amine and/or its main metabolite in most of the brain regions studied, particularly 3 h after treatment. The results suggest that NAP might interfere with the processes regulating brain monoamine metabolism, either locally or indirectly by altering steroid feedback to brain centres, and thus disrupt endocrine control of reproductive development through the brain–pituitary axis.

Keywords

Dopamine Serotonin Naphthalene Polycyclic aromatic hydrocarbons Vitellogenesis Trout 

Notes

Acknowledgements

This work was supported by grants VEM2003-20062 (Ministerio de Ciencia y Tecnología and FEDER, Spain), and PGIDT04PXIC31208PN (Xunta de Galicia, Spain), to J.L. Soengas, and grant AGL2004-08137-c04-03/ACU (Ministerio de Educación y Ciencia and FEDER, Spain) to J.M. Míguez. Manuel Gesto is the recipient of a Xunta de Galicia predoctoral fellowship.

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Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Manuel Gesto
    • 1
  • Adrián Tintos
    • 1
  • Rosa Álvarez
    • 2
  • José L. Soengas
    • 1
  • Jesús M. Míguez
    • 1
  1. 1.Laboratorio de Fisiología Animal, Departamento de Biología Funcional y CC de la Salud, Facultad de BiologíaUniversidad de VigoVigoSpain
  2. 2.Laboratorio de Biología Celular, Departamento de Biología Funcional y CC de la Salud, Facultad de BiologíaUniversidad de VigoVigoSpain

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