Alterations in the brain monoaminergic neurotransmitters of rainbow trout related to naphthalene exposure at the beginning of vitellogenesis
- 146 Downloads
The contents of dopamine (DA), noradrenaline (NA), serotonin (5HT), and some related metabolites were studied in different brain regions of rainbow trout at two different stages of sexual maturation (at the beginning of vitellogenesis), after naphthalene (NAP) administration. The effects of NAP varied according to duration of exposure, brain region and vitellogenesis stage of the trout, and were more significant during previtellogenesis. The changes observed in DA metabolism were generally stimulatory after exposure for 3 h, and either stimulatory or inhibitory (depending on the brain regions) after exposure for 3 days to NAP. NA levels were altered by NAP in various brain regions, but only during previtellogenesis. With respect to 5HT, treatment with NAP reduced levels of the amine and/or its main metabolite in most of the brain regions studied, particularly 3 h after treatment. The results suggest that NAP might interfere with the processes regulating brain monoamine metabolism, either locally or indirectly by altering steroid feedback to brain centres, and thus disrupt endocrine control of reproductive development through the brain–pituitary axis.
KeywordsDopamine Serotonin Naphthalene Polycyclic aromatic hydrocarbons Vitellogenesis Trout
This work was supported by grants VEM2003-20062 (Ministerio de Ciencia y Tecnología and FEDER, Spain), and PGIDT04PXIC31208PN (Xunta de Galicia, Spain), to J.L. Soengas, and grant AGL2004-08137-c04-03/ACU (Ministerio de Educación y Ciencia and FEDER, Spain) to J.M. Míguez. Manuel Gesto is the recipient of a Xunta de Galicia predoctoral fellowship.
- Bromage N, Cumaranatunga R (1988) Egg production in the rainbow trout. In: Muir F, Roberts J (eds) Recent advances in aquaculture. Croom Helm, London, pp 63–138Google Scholar
- Evanson M, Van der Kraak GJ (2001) Stimulatory effects of selected PAHs on testosterone production in goldfish and rainbow trout and possible mechanisms of action. Comp Biochem Physiol C 130:249–258Google Scholar
- Gesto M, Tintos A, Soengas JL, Míguez JM (2006) Effects of acute and prolonged naphthalene exposure on brain monoaminergic neurotransmitters in rainbow trout (Oncorhynchus mykiss). Comp Biochem Physiol C 144:173–183Google Scholar
- Heintz RA, Rice SD, Wertheimer AC, Bradshaw RF, Thrower FP, Joyce JE et al (2000) Delayed effects on growth and marine survival of pink salmon (Oncorhynchus gorbuscha) after exposure to crude oil during embryonic development. Mar Ecol Prog Ser 208:205–216. doi:10.3354/meps208205 CrossRefGoogle Scholar
- Incardona JP, Carls MG, Teraoka H, Sloan CA, Collier TK, Scholz NL (2005) Aryl hydrocarbon receptor-independent mediated toxicity of weathered crude oil during fish development. Environ Health Perspect 133:1755–1762Google Scholar
- Meek J (1994) Catecholamines in the brain of Osteichthyes. In: Smeets WJAJ, Reiner A (eds) Phylogeny and development of catecholamine systems in the CNS of vertebrates. Cambridge University Press, Cambridge, pp 49–76Google Scholar
- Saligaut C, Bailhache T, Salbert C, Breton B, Jego P (1990) Dynamic characteristics of serotonin and dopamine metabolism in the rainbow trout brain: a regional study using liquid chromatography with electrochemical detection. Fish Physiol Biochem 8:199–205. doi:10.1007/BF00004458 CrossRefGoogle Scholar
- Saligaut C, Salbert G, Bailhache T, Bennani S, Jego P (1992a) Serotonin and dopamine turnover in the female rainbow trout (Oncorhynchus mykiss) brain and pituitary: changes during the annual reproductive cycle. Gen Comp Endocrinol 85:261–268. doi:10.1016/0016-6480(92)90010-H PubMedCrossRefGoogle Scholar
- Saligaut C, Garnier DH, Bennani S, Salbert G, Bailhache T, Jego P (1992b) Effects of estradiol on brain aminergic turnover of the female rainbow trout (Oncorhynchus mykiss) at the beginning of vitellogenesis. Gen Comp Endocrinol 88:209–216. doi:10.1016/0016-6480(92)90252-F PubMedCrossRefGoogle Scholar