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Familial Cancer

, Volume 18, Issue 3, pp 363–367 | Cite as

Hereditary gastric cancer: what’s new? Update 2013–2018

  • Rachel S. van der Post
  • Carla Oliveira
  • Parry Guilford
  • Fátima CarneiroEmail author
Review

Abstract

Around 10–20% of gastric cancer patients have relatives with a diagnosis of GC and in 1–3% of patients a genetic cause can be confirmed. Histopathologically, GC is classified into intestinal-type, with glandular growth, and diffuse-type with poorly cohesive growth pattern often with signet ring cells. Familial or hereditary GC is classified into hereditary diffuse GC (HDGC), familial intestinal GC (FIGC) and polyposis forms. This review focuses on recent research findings and new concepts of hereditary GC.

Keywords

Hereditary diffuse gastric cancer E-Cadherin Stomach 

Notes

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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  • Rachel S. van der Post
    • 1
  • Carla Oliveira
    • 2
    • 3
    • 4
  • Parry Guilford
    • 5
  • Fátima Carneiro
    • 2
    • 3
    • 4
    Email author
  1. 1.Department of PathologyRadboud university medical centreNijmegenThe Netherlands
  2. 2.i3S - Instituto de Investigação e Inovação em SaúdeUniversity of PortoPortoPortugal
  3. 3.Ipatimup - Institute of Molecular Pathology and ImmunologyUniversity of PortoPortoPortugal
  4. 4.Faculty of MedicineUniversity of PortoPortoPortugal
  5. 5.Cancer Genetics Laboratory, Department of Biochemistry, Centre for Translational Cancer Research, Te Aho MatatūUniversity of OtagoDunedinNew Zealand

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