Association of genetic variations in RTN4 3′-UTR with risk for clear cell renal cell carcinoma
- 155 Downloads
Nogo proteins play an important role in the apoptosis of cells, especially in tumor cells. The present study was conducted to evaluate whether the TATC (rs71682980) and CAA (rs34917480) insertion/deletion polymorphisms of RTN4 3′-UTR are associated with clear cell renal cell carcinoma (ccRCC). These two polymorphisms were genotyped in 308 ccRCC patients and 466 healthy controls by polymerase chain reaction polyacrylamide gel electrophoresis (PCR-PAGE). Significantly reduced ccRCC risk was observed to be associated with the TATCins/ins genotype carriers (Versus TATCdel/del: adjusted OR 0.53, 95% CI 0.32–0.87, P = 0.022; Versus TATCdel/del−del/ins: adjusted OR 0.57, 95% CI 0.36–0.92, P = 0.017). After performing stratification analysis, the frequency of TATCins/ins genotype was observed to be significantly higher in patients with N0 compared the patients with N1 (P = 0.003). The present study provide evidence for the first time that the TATC insertion/deletion polymorphism in RTN4 3′-UTR may contributes to ccRCC risk in Chinese Han population.
KeywordsRTN4 Nogo proteins Clear cell renal cell carcinoma Polymorphism Genetic susceptibility
This work was supported by the National Natural Science Foundation of China (Nos. 81172440, 81172494, 81272821 and 81202023); the Applied Basic Research Programs of Science and Technology Commission Foundation of Sichuan Province (No. 2012SZ0026); and the Science Foundation for The Excellent Youth Scholars of Sichuan University (No. 2011SCU04A16).
Yan Pu is responsible for statistical design and analysis.
Compliance with ethical standards
Conflict of interest
No competing financial interests exist.
- 11.Nickerson ML, Warren MB, Toro JR, Matrosova V, Glenn G, Turner ML, Duray P, Merino M, Choyke P, Pavlovich CP et al (2002) Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dube syndrome. Cancer cell 2:157–164CrossRefPubMedGoogle Scholar