Familial Cancer

, Volume 10, Issue 3, pp 521–528

Serum levels of IGF-I and BRCA penetrance: a case control study in breast cancer families

  • Patrizia Pasanisi
  • Eleonora Bruno
  • Elisabetta Venturelli
  • Siranoush Manoukian
  • Monica Barile
  • Bernard Peissel
  • Clelia De Giacomi
  • Bernardo Bonanni
  • Jacopo Berrino
  • Franco Berrino
Article

DOI: 10.1007/s10689-011-9437-y

Cite this article as:
Pasanisi, P., Bruno, E., Venturelli, E. et al. Familial Cancer (2011) 10: 521. doi:10.1007/s10689-011-9437-y

Abstract

High serum levels of insulin-like growth factor I (IGF-I) are associated with an increased risk of sporadic breast cancer (BC). The aim of the present work is to evaluate the association between IGF-I and hereditary BC risk, using a case–control approach. The work represents an “ad interim” cross-sectional analysis of an ongoing study with a prospective design whose aim is to recruit a cohort of women belonging to high genetic risk families to test potential modulators of penetrance and prognosis. The odd of exposure to high serum IGF-I levels among women with a previous diagnosis of BC (“cases”) was compared with the odd among unaffected “controls”. The odds ratio (OR) and 95% confidence intervals (CIs) were estimated by unconditional logistic regression, controlling for confounders. We analysed 308 women (209 cases and 99 controls) at high genetic risk of BC. The adjusted OR of BC for the upper tertile of serum IGF-I versus the lowest one was 3.5 (95%CI 1.4–8.8). Excluding from the analysis 64 women under current Tamoxifen or GnRH analogues treatment, the adjusted OR of BC became 3.7 (95%CI 1.4–9.9). The association became stronger restricting the analysis to the 161 women (97 cases and 64 controls) with a proven BRCA mutation. If confirmed by a prospective approach, the association between IGF-I and familial BC will open further options for reducing BC risk in susceptible women.

Keywords

IGF-I BRCA genes Penetrance Breast cancer Primary prevention 

Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Patrizia Pasanisi
    • 1
    • 5
  • Eleonora Bruno
    • 1
  • Elisabetta Venturelli
    • 1
  • Siranoush Manoukian
    • 2
  • Monica Barile
    • 3
  • Bernard Peissel
    • 2
  • Clelia De Giacomi
    • 4
  • Bernardo Bonanni
    • 3
  • Jacopo Berrino
    • 1
  • Franco Berrino
    • 1
  1. 1.Etiological and Preventive Epidemiology UnitFondazione IRCCS Istituto Nazionale dei TumoriMilanItaly
  2. 2.Medical Genetics UnitFondazione IRCCS Istituto Nazionale dei TumoriMilanItaly
  3. 3.Division of Cancer Prevention and GeneticsIstituto Europeo di OncologiaMilanItaly
  4. 4.Division of Medical OncologyCentro di Riferimento OncologicoAvianoItaly
  5. 5.Department of Preventive and Predictive MedicineFondazione IRCCS Istituto Nazionale dei TumoriMilanItaly

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