Younger age-at-diagnosis for familial malignant testicular germ cell tumor
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One of the clinical hallmarks of hereditary cancer susceptibility disorders is a younger-than-usual age at diagnosis. Familial aggregation of testicular germ cell tumor (TGCT) has been reported, but data on whether familial TGCT cases are diagnosed at an earlier age are inconclusive. Here we compared the age at diagnosis of familial TGCT cases with that of population cases in several countries. Familial TGCT is defined as affected individuals from families with ≥2 cases of TGCT. Age at diagnosis of familial cases from the United States, Canada, United Kingdom, Australia and New Zealand, Norway, and Hungary was compared to cases identified in population-based cancer registries from the respective country, using the generalized estimation equation method. Age at diagnosis was statistically significantly younger for familial TGCT cases from North America (P = 0.024), the United Kingdom (P < 0.0001), and Australia and New Zealand (P = 0.0033) compared with population cases. When stratified by histology, the difference in age at diagnosis distribution between familial and population cases was observed for seminoma cases from North America (P = 0.002) and the United Kingdom (P < 0.0001) and non-seminoma cases from the United Kingdom (P = 0.029) and Australia and New Zealand (P = 0.0023). In summary, we found that the age at diagnosis for familial TGCT cases is, on the average, 2–3 years younger than that for the population cases in North America, United Kingdom, and Australia and New Zealand. The younger age at diagnosis might be suggestive of a genetic basis for familial TGCT.
KeywordsAge at diagnosis Familial Non-seminoma Population-based testicular cancer Seminoma Testicular germ cell tumor
International testicular cancer linkage consortium
Testicular germ cell tumor
We would like to thank Dr. Parry Guilford for his contribution to the familial TGCT cases. We also thank Istvan Gaudi (Cancer Registry of National Institute of Oncology, Budapest, Hungary) and Sue Westlake (Social & Health Analysis & Reporting Division, Office for National Statistics, UK) for their contribution from the cancer registries. This research was funded in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, and supported by contracts N02-CP-11019 and N02-CP-65504 with Westat, Incorporated. The authors have no conflict of interest or financial disclosures to report.
- 1.Ferlay J, Bray F, Pisani P et al (eds) (2004) GLOBOCAN 2002: cancer incidence, mortality and prevalence worldwide. IARC Press, LyonGoogle Scholar
- 6.Harland SJ, Daugaard G, Horwich A et al (2006) The familial influence on bilateral testicular germ cell cancer: medical Research Council study TER2. Annual Meeting Proceedings. J Clin Oncol 24, Abstract no. 4590Google Scholar
- 15.Mai PL, Friedlander M, Tucker K et al. (2009) The international testicular cancer linkage consortium: a clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred. Urol Oncol. doi: 10.1016/J.urolonc.2008.10.004
- 21.McCullagh P, Nelder JA (1989) Generalized linear models, 2nd edn. Chapman and Hall/CRC, LondonGoogle Scholar