Familial Cancer

, Volume 5, Issue 4, pp 309–321 | Cite as

Family History, and Impact on Clinical Presentation and Prognosis, in a Population-based Breast Cancer Cohort from the Stockholm County

  • Sara Margolin
  • Hemming Johansson
  • Lars Erik Rutqvist
  • Annika Lindblom
  • Tommy Fornander
Article

Abstract

Background

The aim of the present study was to define the proportion of different levels of family history in a cohort of consecutive breast cancer patients from the Stockholm region, and to assess whether familial breast cancer has phenotypic traits different from those of sporadic patients.

Methods

All incident breast cancer patients in a 19-month period were eligible for the study and 70% (489/696) participated. The family history and clinical parameters were obtained from questionnaires and medical records.

Results

In total 35% had a family history. Age at onset was 58.9 years in the familial group vs. 60.7 years in the sporadic patients (= 0.14) and 8% of the familial patients had bilateral breast cancer compared to 4% in the sporadic group (= 0.08). There were 31% node positive tumors in the sporadic group vs. 22% in the cases with family history (= 0.04). Hormonal background, treatment and prognosis (median follow-up 4.7 years) were not related to family history.

Conclusion

In addition to high-risk familial breast and breast-ovarian cancer, constituting about 10% of all breast cancer cases, another 25% of the breast cancer cases have a family history, a group hypothetically valuable for association studies on low-risk genes. In contrast to previous reports, we did not observe a relationship between family history and phenotypic traits. A possible explanation for this can be different study design. The considerable heterogeneity in familial breast cancer means that different criteria for familiality can influence the result. Furthermore, our study was prospective and population based and included paternal inheritance.

Keywords

Population based Breast cancer Family history Prognosis 

Abbreviation

ER

estrogen receptor

HR

hazard rate ratio

RR

relative risk

CI

confidence interval

FH+

patients with family history

NS

no statistically significant difference

PgR

progesterone receptor

BRCA

breast cancer gene

HRT

hormone replacement therapy

FH

family history

FH−

sporadic patients

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Copyright information

© Springer Science+Business Media B.V. 2006

Authors and Affiliations

  • Sara Margolin
    • 1
  • Hemming Johansson
    • 1
  • Lars Erik Rutqvist
    • 1
  • Annika Lindblom
    • 2
  • Tommy Fornander
    • 1
  1. 1.Department of OncologyKarolinska University Hospital at SödersjukhusetStockholmSweden
  2. 2.Department of Molecular MedicineKarolinska InstituteStockholmSweden

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