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Familial Cancer

, Volume 4, Issue 3, pp 233–237 | Cite as

The Incidence of Lynch Syndrome

  • Albert de la ChapelleEmail author
Article

Abstract

Lynch syndrome (LS) here is defined as carriership of a deleterious mismatch repair (MMR) gene mutation. By screening for MMR gene mutations in unselected colorectal or endometrial cancer patients, it was found that the prevalence of LS in colorectal and endometrial cancer patients is 1–3%. On extrapolation to the entire population, the incidence of LS is between 1:2000 and 1:660. As all screening methods are less than 100% sensitive, the above figures are underestimates.

Keywords

frequency hereditary nonpolyposis colorectal cancer incidence Lynch syndrome mismatch repair gene mutations prevalence 

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Copyright information

© Springer 2005

Authors and Affiliations

  1. 1.Professor and Director, Human Cancer Genetics Program, Comprehensive Cancer CenterThe Ohio State UniversityColumbusUSA

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