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Quantitative genetic evidence for trade-off between growth and resistance to oxidative stress in a wild bird

Abstract

Why do animals not grow at their maximal rates? It has been recently proposed that fast growth leads to the accumulation of cellular damages due to oxidative stress, influencing subsequent performances and life span. Therefore, the trade-off between fast growth and oxidative stress may potentially function as an important constraint in the evolution of growth trajectories. We test this by examining a potential antagonistic pleiotropy between growth and blood resistance to controlled free radical attack in a wild bird using a cross-fostering design and robust quantitative genetic analyses. In the yellow-legged gull Larus michahellis, decreased resistance to oxidative stress at age 8 days was associated with faster growth in mass, across the first 8 days of life, suggesting a trade-off between mass growth and oxidative-stress-related somatic maintenance. We found a negative genetic correlation between chick growth and resistance to oxidative stress, supporting the presence of the genetic trade-off between the two traits. Therefore, investment of somatic resources in growth could be constrained by resistance to oxidative stress in phenotypic and genetic levels. Our results provide first evidence for a potential genetic trade-off between life-history and underlying physiological traits in a wild vertebrate. Future studies should explore genetic trade-offs between life-history traits and other oxidative-stress-related traits.

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Acknowledgments

We are grateful to C. Alonso-Alvarez for very helpful comments on the earlier manuscript. We thank C. Pérez for invaluable help during the fieldwork, Ester Ferrero for molecular sexing, M. Lores for advice in preparing for the saline buffer, and J. Dominguez and L. Sampedro for logistic helps. Fieldwork in Sálvora Island depended on the generous support and friendship of P. Fernandez Bouzas, M. Caneda, M. Costas, P. Rivadulla, J. Torrado, P. Valverde and P. Vázquez of the Parque Nacional, and los fareros, P. Pertejo and J. Vilches. Finance was provided by the Spanish Ministerio de Ciencia e Innovación (CGL2009-10883-C02-01). S.-Y. K. is supported by the Isidro Parga Pondal fellowship (Xunta de Galicia), J. C. N. by an FPI grant (MICINN) and J. M. by a Juan de la Cierva Fellowship (MICINN). The study was done under permissions by the Parque Nacional das Illas Atlánticas and Xunta de Galicia, and all the field procedures we performed complied with the current laws of Spain.

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Correspondence to Sin-Yeon Kim.

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Kim, S., Noguera, J.C., Morales, J. et al. Quantitative genetic evidence for trade-off between growth and resistance to oxidative stress in a wild bird. Evol Ecol 25, 461–472 (2011). https://doi.org/10.1007/s10682-010-9426-x

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Keywords

  • Antagonistic pleiotropy
  • Heritability
  • Life-history evolution
  • Reactive oxygen species
  • Somatic growth
  • Trade-off