The geographic distribution of trace elements in the environment: the REGARDS study
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Research on trace elements and the effects of their ingestion on human health is often seen in scientific literature. However, little research has been done on the distribution of trace elements in the environment and their impact on health. This paper examines what characteristics among participants in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study are associated with levels of environmental exposure to arsenic, magnesium, mercury, and selenium. Demographic information from REGARDS participants was combined with trace element concentration data from the US Geochemical Survey (USGS). Each trace element was characterized as either low (magnesium and selenium) or high (arsenic and mercury) exposure. Associations between demographic characteristics and trace element concentrations were analyzed with unadjusted and adjusted logistic regression models. Individuals who reside in the Stroke Belt have lower odds of high exposure (4th quartile) to arsenic (OR 0.33, CI 0.31, 0.35) and increased exposure to mercury (OR 0.65, CI 0.62, 0.70) than those living outside of these areas, while the odds of low exposure to trace element concentrations were increased for magnesium (OR 5.48, CI 5.05, 5.95) and selenium (OR 2.37, CI 2.22, 2.54). We found an association between levels of trace elements in the environment and geographic region of residence, among other factors. Future studies are needed to further examine this association and determine whether or not these differences may be related to geographic variation in disease.
KeywordsTrace elements REGARDS study Stroke
This research project is supported by a cooperative agreement U01 NS041588 from the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Department of Health, and Human Service. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Neurological Disorders and Stroke or the National Institutes of Health. Representatives of the funding agency have been involved in the review of the manuscript but not directly involved in the collection, management, analysis, or interpretation of the data. The authors thank the other investigators, the staff, and the participants of the REGARDS study for their valuable contributions. A full list of participating REGARDS investigators and institutions can be found at http://www.regardsstudy.org
Additional funding for this work was provided by grants from the National Institutes of Health (R01 ES021735) and National Institutes of Health Heart, Lung, and Blood Institute (T32HL07988).
Compliance with ethical standards
All REGARDS participants provided written informed consent, and Institutional Review Board approval was obtained at all participating institutions (Howard et al. 2005).
- Abbey, D. E., Ostro, B. E., Petersen, F., & Burchette, R. J. (1994). Chronic respiratory symptoms associated with estimated long-term ambient concentrations of fine particulates less than 2.5 microns in aerodynamic diameter (PM2.5) and other air pollutants. Journal of Exposure Analysis and Environmental Epidemiology, 5(2), 137–159.Google Scholar
- Al-Hamdan, M. Z., Crosson, W. L., Economou, S. A., Estes Jr, M. G., Estes, S. M., Hemmings, S. N., ... & McClure, L. A. (2014). Environmental public health applications using remotely sensed data. Geocarto International 29(1): 85–98.Google Scholar
- Alissa, E. M., Bahijri, S. M., & Ferns, G. A. (2003). The controversy surrounding selenium and cardiovascular disease: a review of the evidence. Medical Science Monitor, 9(1), RA9–RA18.Google Scholar
- Briggs, P. H. (2002). Chapter F: the determination of twenty-seven elements in aqueous samples by inductively coupled plasma-atomic emission spectrometry. Analytical methods for chemical analysis of geologic and other materials.Google Scholar
- Bryant, B. I., & Mohai, P. (1992). Race and the incidence of environmental hazards.Google Scholar
- Bullard, R. D., & Wright, B. H. (1993). Environmental justice for all: community perspectives on health and research needs. Toxicology and Industrial Health, 9(5), 821–841.Google Scholar
- Chen, C. J., Hsueh, Y. M., Lai, M. S., Shyu, M. P., Chen, S. Y., Wu, M. M., ... & Tai, T. Y. (1995). Increased prevalence of hypertension and long-term arsenic exposure. Hypertension, 25(1): 53–60.Google Scholar
- Cromartie, J., Bucholtz, S. (2008). Defining the "rural" in rural America. Amber Waves. https://www.ers.usda.gov/amber-waves/2008/june/defining-the-rural-in-rural-america. Accessed 26 January 2017.
- Go, A. S., Mozaffarian, D., Roger, V. L., Benjamin, E. J., Berry, J. D., Blaha, M. J., ... & Stroke, S. S. (2014). Heart disease and stroke statistics—2014 update: a report from the American Heart Association. Circulation, 129(3): e28.Google Scholar
- Hageman, P. L., Brown, Z. A., & Welsch, E. (2002). Arsenic and selenium by flow injection or continuous flow-hydride generation-atomic absorption spectrometry. US Geological Survey Open-File Report: 1–9.Google Scholar
- Lai, M. S., Hsueh, Y. M., Chen, C. J., Shyu, M. P., Chen, S. Y., Kuo, T. L., ... & Tai, T. Y. (1994). Ingested inorganic arsenic and prevalence of diabetes mellitus. American Journal of Epidemiology, 139(5): 484–492.Google Scholar
- Masironi, R. (1969). Trace elements and cardiovascular diseases. Bulletin of the World Health Organization, 40(2), 305.Google Scholar
- Rylander, R., Bonevik, H., & Rubenowitz, E. (1991). Magnesium and calcium in drinking water and cardiovascular mortality. Scandinavian Journal of Work, Environment & Health: 91–94.Google Scholar
- Salonen, J. T., Seppänen, K., Nyyssönen, K., Korpela, H., Kauhanen, J., Kantola, M., et al. (1995). Intake of mercury from fish, lipid peroxidation, and the risk of myocardial infarction and coronary, cardiovascular, and any death in eastern Finnish men. Circulation, 91(3), 645–655.CrossRefGoogle Scholar
- Services, U. D. o. H. a. H. (1999). Toxicological profile for mercury.Google Scholar
- Services, U. D. o. H. a. H. (2003). Toxicological profile for selenium.Google Scholar
- Services, U. D. o. H. a. H. (2007). Toxicological profile for arsenic.Google Scholar
- Skoczyńska, A., Poręba, R., Steinmentz-Beck, A., Martynowicz, H., Affelska-Jercha, A., Turczyn, B., ... & Jędrychowska, I. (2009). The dependence between urinary mercury concentration and carotid arterial intima-media thickness in workers occupationally exposed to mercury vapour. International Journal of Occupational Medicine and Environmental Health, 22(2): 135–142.Google Scholar
- Srivastava, S., Chen, Y., & Barchowsky, A. (2009). Arsenic and cardiovascular disease. Toxicological Sciences, 107(2), 312–323.Google Scholar
- Stranges, S., Marshall, J. R., Trevisan, M., Natarajan, R., Donahue, R. P., Combs, G. F., ... & Reid, M. E. (2006). Effects of selenium supplementation on cardiovascular disease incidence and mortality: secondary analyses in a randomized clinical trial. American Journal of Epidemiology, 163(8): 694–699.Google Scholar
- [USEPA], U. E. P. A. (1997). Mercury study report to Congress, vols. 1–8. Washington (DC), Office of Air Quality Planning and Standards and Office of Research and Development, Report no. EPA-452/R-97–005.Google Scholar
- [USGS], U. G. S. (2013). Water Hardness and Alkalinity.Google Scholar
- Virtanen, J. K., Voutilainen, S., Rissanen, T. H., Mursu, J., Tuomainen, T. P., Korhonen, M. J., ... & Salonen, J. T. (2005). Mercury, fish oils, and risk of acute coronary events and cardiovascular disease, coronary heart disease, and all-cause mortality in men in eastern Finland. Arteriosclerosis, Thrombosis, and Vascular Biology, 25(1): 228–233.Google Scholar
- (WHO), W. H. O (2007). Exposure to mercury: a major public health concern. Geneva: WHO.Google Scholar